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Updated: Jun 14, 2026

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动态ctDNA跟踪对接受新辅助化疗的三阴性乳腺癌患者复发风险进行分层化

Shunying Li1,2, Yudong Li1,2, Wei Wei3

  • 1Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Nature communications
|March 22, 2025
PubMed
概括

循环瘤DNA (ctDNA) 可以预测新辅助化疗后早期三阴性乳腺癌 (eTNBC) 的结果. 治疗后ctDNA水平和全身瘤负担模型有效地识别高复发风险的患者.

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...