在接受新辅助化疗的老年乳腺癌患者中实现治疗目标
Eda Caliskan Yildirim1, Elif Atag2, Huseyin Salih Semiz2
1Department of Internal Medicine, Division of Medical Oncology, Dokuz Eylul University, Izmir, 35340, Turkey. caliskan_eda@yahoo.com.
Scientific reports
|March 22, 2025
概括
老年乳腺癌患者在接受新辅助化疗 (NAC) 的治疗反应与年轻患者相似. 年龄不应该限制治疗决策,但老年人经历了更高的毒性率.
科学领域:
- 在瘤学瘤学.
- 老年医学 老年医学
- 乳腺癌研究研究 乳腺癌研究
背景情况:
- 新辅助化疗 (NAC) 是局部晚期乳腺癌的标准,特别是HER2阳性和三阴性亚型.
- 年代年龄对NAC疗效和结果的影响还不清楚.
- 现有的研究还没有充分解决老年乳腺癌患者的治疗反应.
研究的目的:
- 为了比较NAC在老年与年轻乳腺癌患者的疗效和结果.
- 评估与年龄相关的下降阶段差异,病理完整反应 (pCR) 和治疗毒性.
- 为老年乳腺癌患者提供个性化治疗策略的信息.
主要方法:
- 对接受NAC并随后接受手术的535名患者 (2010-2021) 的回顾性分析.
- 患者被分为老年 (≥65岁) 和年轻的队列.
- 评估的关键结果包括乳腺和腹下降阶段,pCR和毒性等级.
主要成果:
- 没有观察到与年龄相关的显著差异,包括手术结果,乳腺/关下降阶段或pCR率.
- 年轻的患者更有可能接受剂量密集的环素疗法 (71.7%vs38.5%).
- 年龄较大的患者患上3-4级毒性的发病率较高 (71%对46.4%).
结论:
- 老年患者的瘤治疗结果与NAC的年轻患者相似.
- 仅仅是时间学年龄不应该成为乳腺癌中NAC的障碍.
- 综合老年医学评估对于管理老年人治疗毒性至关重要.
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