通过JAK-STAT通路,YTHDF2促进了口腔状细胞癌的转移
Zhezheng Chen1,2,3, Dan Zhao1,2, Yamin Yuan2
1Department of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital of Southwest Medical University, Luzhou, 646000, China.
Scientific reports
|March 22, 2025
概括
通过激活JAK-STAT通路,YTHDF2蛋白促进口腔状细胞癌 (OSCC) 的生长和扩散. 这一发现表明YTHDF2是OSCC诊断和治疗的潜在生物标志物.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 包括YTHDF2在内的RNA结合蛋白与癌症进展有关.
- 在口腔状细胞癌 (OSCC) 中YTHDF2的特定作用和机制尚不清楚.
研究的目的:
- 研究OSCC中YTHDF2的表达,功能和分子机制.
- 评估YTHDF2作为OSCC的潜在预后标志物.
主要方法:
- 在公共数据库和OSCC患者样本中分析YTHDF2表达.
- 在体外功能测试 (增殖,迁移,入侵) 评估YTHDF2对OSCC细胞的影响.
- RNA测序 (RNA-seq) 用于识别YTHDF2-调制的信号通路.
- 确定路径的实验验证,包括JAK-STAT信号.
主要成果:
- 在OSCC组织和细胞中,YTHDF2的表达显著上调.
- 升高的YTHDF2水平与晚期临床阶段,不良的病理等级和患者生存率降低相关.
- 抑制YTHDF2可以抑制OSCC细胞的增殖,迁移和入侵.
- 沉默YTHDF2抑制了JAK-STAT信号通路,这种信号通路可以通过STAT3激活来逆转.
结论:
- 通过对JAK-STAT信号通路的积极调节,YTHDF2促进OSCC的扩散,转移和入侵.
- YTHDF2代表了OSCC诊断和治疗向的有希望的预后标记.
相关概念视频
The JAK-STAT Signaling Pathway
8.6K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
8.6K
Metastasis
5.5K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.5K
mTOR Signaling and Cancer Progression
3.7K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.7K
Mitogens and the Cell Cycle
6.4K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.4K
TGF - β Signaling Pathway
7.2K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
7.2K
Canonical Wnt Signaling Pathway
8.6K
The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
8.6K


