细菌素的生产促进了抗菌素耐药的Enterococcus faecium在医院内出现
Emma G Mills1, Katharine Hewlett2, Alexander B Smith2
1Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Nature microbiology
|March 22, 2025
概括
抗万科胺素的Enterococcus faecium (VREfm) 血统的替代是由细菌素T8驱动的. 这种细菌素提供了竞争优势,影响了VREfm在医疗保健环境中的演变.
科学领域:
- 微生物学 微生物学
- 基因组学就是基因组学.
- 传染性疾病 传染性疾病
背景情况:
- 鼻腔病原体抗菌素耐药性肠球菌 (Enterococcus faecium,VREfm) 导致高死亡率的血液感染.
- 了解医疗保健环境中的VREfm血统转移至关重要,但目前缺乏.
- VREfm胃肠道殖民是侵入性感染的前体.
研究的目的:
- 为了研究VREfm血统替代的基因组基础.
- 识别导致VREfm人口在医疗环境中的转变的因素.
- 探索特定遗传元素在VREfm竞争优势中的作用.
主要方法:
- 从2017-2022年对710个VREfm临床分离物的测序.
- 用全球15631个VREfm基因组进行比较基因组分析 (2002-2022年).
- 在体外和体内 (老鼠肠道殖民) 功能测试.
主要成果:
- 基因组分析显示,多克隆VREfm种群具有显著的聚类,表明高传播率.
- 新兴的ST80和ST117VREfm血统取代了以前在全球和本地占主导地位的ST17血统.
- 新兴的血统携带了细菌素T8,在试验室和小鼠肠道殖民中赋予了竞争优势.
结论:
- 细菌素T8携带与特定VREfm血统的出现和全球传播密切相关.
- 细菌素T8介导的竞争可能推动了VREfm谱系替代事件.
- 研究结果提供了关于VREfm在医疗保健环境中的进化动态的见解.
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