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Updated: May 21, 2025

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基因工程巨细胞逆转了免疫抑制性瘤微环境,并提高了TNBC的免疫治疗疗效

Ranran Jiang1, Liechi Yang2, Xin Liu3

  • 1Department of Oncology, Nanjing Medical University, 101 Longmian Avenue, Nanjing, Jiangsu 211166, China; Cancer Institute, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, Jiangsu 221004, China; Center of Clinical Oncology, The Affiliated Hospital of Xuzhou Medical University, 99 Huaihai Road, Xuzhou, Jiangsu 221002, China; Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, Jiangsu 221004, China; Department of Oncology, The Affiliated Hospital of Xuzhou Medical University, 99 Huaihai Road, Xuzhou, Jiangsu 221002, China.

Molecular therapy : the journal of the American Society of Gene Therapy
|March 22, 2025
PubMed
概括

基因工程巨细胞 (GEMs) 重新编程与瘤相关的巨细胞,以对抗三阴性乳腺癌 (TNBC). 这种新型免疫疗法策略逆转了免疫抑制瘤微环境,增强了抗瘤免疫反应并抑制了瘤生长.

关键词:
在CXCL9中使用.GEMs是GEMs,它们是GEMs.在IL-12中,IL-12是最重要的.这就是TAMs.在TME中,它是最重要的.经过基因工程改造的巨细胞活生生的巨细胞介导的基因传递瘤免疫微环境是一个微环境.与瘤相关的巨细胞.

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