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基于INSTI的单片药片与多片药片治疗方案之间的错误发生率的比较在住院患者的环境中
Denise Kelley1,2, Kayla Blackmon2, Brian L Nguyen3
1University of Texas, College of Pharmacy, Austin, TX, USA.
在住院的艾滋病毒患者中,从单片剂方案 (STR) 转换为抗逆转录病毒疗法 (ART) 的多片剂方案 (MTR),增加了药物错误. 使用MTR时需要保持警,以确保患者的安全和有效的治疗.
科学领域:
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
- 医院 医院药房 医院药房
背景情况:
- 抗逆转录病毒疗法 (ART) 错误在住院的人类免疫缺陷病毒 (HIV) 患者中很常见,可能导致治疗失败和毒性.
- 虽然ART可用于单片剂疗法 (STR) 或多片剂疗法 (MTR),但基于药片数量的住院患者错误率的数据有限.
研究的目的:
- 在住院艾滋病毒成年患者中,比较基于比克特格拉维尔的单片剂疗法 (STR) 和基于多乐格拉维尔的多片剂疗法 (MTR) 之间的药物错误发生率.
主要方法:
- 一项多中心,回顾性,观察性研究评估了接受HIV治疗ART的514名成年住院患者.
- 主要结局是当ART作为STR与MTR分发时错误的复合发病率.
- 二级终点包括错误类型,纠正时间和药剂师参与.
主要成果:
- 复合错误发生率在STR组 (23%) 与MTR组 (31.5%;P = 0.029) 相比显著较低.
- 与剂量相关的错误,特别是对于脏或肝脏的调整,在MTR组显着更高.
- 在这两组中,每次遇到的误差大约为一个,平均校正时间为一天.
结论:
- 在住院治疗中,以INSTI为基础的ART作为STR的使用可能会减少药物错误并改善患者的护理.
- 然而,STR可能无法完全解决器官功能障碍中的剂量错误,在使用MTR时,提高警至关重要.
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