作为急性损伤结果的预后标记的可溶平均Klotho水平:90天的随访研究
ShaSha Li1, Yan Liang2, JianHua Feng3
1Clinical Research & Lab Centre, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, Jiangsu, China.
Biomarkers in medicine
|March 22, 2025
概括
在急性损伤 (AKI) 患者中,可溶性Klotho水平较低,并且随着损伤的严重程度而降低. 较低的Klotho平均水平预测了更糟糕的AKI结果,表明其诊断和预测潜力.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 生物化学 生化学
- 临床医学 临床医学
背景情况:
- 克洛托蛋白在脏中丰富,具有保护作用.
- 急性损伤 (AKI) 是一种具有潜在长期后果的重大临床问题.
- 了解AKI的生物标志物对于改善患者管理至关重要.
研究的目的:
- 为了评估AKI患者的血清溶解克洛托 (sKlotho) 水平.
- 在AKI中确定sklotho水平与功能之间的关联.
- 评估sKlotho对短期AKI结果的预测价值.
主要方法:
- 招募了102名AKI患者和30名健康对照.
- 在AKI患者的入院和出院时测量血清sKlotho水平.
- 在90天内跟踪AKI患者,以将平均sKlotho与结果相关联.
主要成果:
- AKI患者的基线sKlotho低于对照组.
- sKlotho水平随着AKI严重程度的下降 (第三阶段与第一到第二阶段).
- 较低的平均sKlotho水平和sKlotho/肌素比率预测了不良的AKI结果.
结论:
- sKlotho水平反映了AKI中的损伤严重程度.
- 平均sKlotho水平与脏不良结果呈反向相关性.
- sKlotho具有作为AKI诊断和预测生物标志物的潜力.
相关概念视频
Blood Studies for Cardiovascular System I: Cardiac Biomarkers
76
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
76
Kidney Structure
68.3K
The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
68.3K
Factors Affecting Renal Clearance: Renal Impairment
45
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
45


