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相关概念视频

Herniated Intervertebral Disc l: Introduction01:29

Herniated Intervertebral Disc l: Introduction

Intervertebral disc herniation refers to the displacement of the nucleus pulposus (the gel-like inner core of the disc) through a tear or weakened area in the annulus fibrosus (the outer fibrous ring). The displaced disc material extends beyond the normal boundaries of the disc space and may compress or irritate nearby spinal nerve roots or, less commonly, the spinal cord.Etiology and Risk FactorsHerniation commonly results from degeneration, in which aging reduces disc hydration and...
Degenerative Disc Disease I: Introduction01:27

Degenerative Disc Disease I: Introduction

Degenerative disc disease is a chronic condition in which intervertebral discs gradually lose structure and function. It is not infectious or autoimmune; rather, it results from age-related biochemical and mechanical changes, influenced by genetic, metabolic, and environmental factors.Structure and Function of DiscsThe spine contains 23 intervertebral discs that absorb load, distribute forces, maintain spacing, and allow flexibility. Each disc consists of a nucleus pulposus, a gel-like core...
Degenerative Disc Disease ll: Pathophysiology01:23

Degenerative Disc Disease ll: Pathophysiology

The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...

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相关实验视频

Updated: May 7, 2026

Optical Sectioning and Visualization of the Intervertebral Disc from Embryonic Development to Degeneration
06:22

Optical Sectioning and Visualization of the Intervertebral Disc from Embryonic Development to Degeneration

Published on: July 8, 2021

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单核转录组学解读了衰老与腰椎间板椎间板间的联系.

Min Wang1,2, Zan He3, Anqi Wang4,5

  • 1Key Laboratory of Organ Regeneration and Reconstruction, State Key Laboratory of Stem Cell and Reproductive Biology, State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.

Protein & cell
|March 22, 2025
PubMed
概括
此摘要是机器生成的。

细胞衰老和减少的核脉动原生细胞 (NPPCs) 驱动腰椎 (LD) 衰老和. 增加NFAT1表达会加剧NPPC衰老,导致LD病理.

关键词:
没有NFAT1的资产衰老的衰老 衰老的衰老发生的发生.核脉 (NP) 是指核脉 (NP) 的一个部分.衰老是一种老化.单核转录组学 单核转录组学

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Fluorescence-Activated Nuclei Negative Sorting of Neurons Combined with Single Nuclei RNA Sequencing to Study the Hippocampal Neurogenic Niche
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Fluorescence-Activated Nuclei Negative Sorting of Neurons Combined with Single Nuclei RNA Sequencing to Study the Hippocampal Neurogenic Niche

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Author Spotlight: Advancing Biomedical Research Through Single Cell Analysis
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Author Spotlight: Advancing Biomedical Research Through Single Cell Analysis

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相关实验视频

Last Updated: May 7, 2026

Optical Sectioning and Visualization of the Intervertebral Disc from Embryonic Development to Degeneration
06:22

Optical Sectioning and Visualization of the Intervertebral Disc from Embryonic Development to Degeneration

Published on: July 8, 2021

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Fluorescence-Activated Nuclei Negative Sorting of Neurons Combined with Single Nuclei RNA Sequencing to Study the Hippocampal Neurogenic Niche
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Fluorescence-Activated Nuclei Negative Sorting of Neurons Combined with Single Nuclei RNA Sequencing to Study the Hippocampal Neurogenic Niche

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Author Spotlight: Advancing Biomedical Research Through Single Cell Analysis
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Author Spotlight: Advancing Biomedical Research Through Single Cell Analysis

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科学领域:

  • 生物医学科学 生物医学科学
  • 细胞生物学 细胞生物学
  • 衰老研究研究 衰老研究

背景情况:

  • 腰椎间盘 (LD) 椎间盘 (LD) 和衰老是显著发病率的常见原因.
  • 了解将LD衰老与结联系起来的分子机制,对于开发有效的治疗方法至关重要.

研究的目的:

  • 研究与LD衰老和带相关的细胞和分子细胞核 (NP) 的变化.
  • 确定导致NP细胞衰老和功能障碍的关键因素.

主要方法:

  • 来自多样化的队列的NP样本的组织学分析.
  • 单核RNA测序以分析分子变化.
  • 细胞衰老和NP原生细胞 (NPPC) 种群与年龄和状况的相关性.

主要成果:

  • 细胞衰老和NPPCs的减少被确定为LD衰老和的中心机制.
  • 观察到与年龄相关的NFAT1表达的增加.
  • NFAT1促进NPPC衰老,有助于LD衰老和.

结论:

  • 细胞衰老和NPPC枯竭是LD衰老和的关键驱动因素.
  • NFAT1在促进NPPC衰老和LD病理学方面发挥着重要作用.
  • 这些发现为LD衰老和带来了新的见解,表明了潜在的治疗点.