抗真菌图:一个独特的工具来追踪真菌耐药性
Zoey Sjogren1, Amanda Bushman1, Jessi Holter1
1Pharmacy, UnityPoint Health, Des Moines, IA, USA.
概括
一种抗真菌剂可以帮助追踪Candida物种的抗真菌耐药性. 该工具有助于指导实证抗真菌治疗的选择,改善患者的治疗结果.
科学领域:
- 医学真菌学 医学真菌学
- 传染性疾病 传染性疾病
- 临床微生物学 临床微生物学
背景情况:
- 美国的Candida感染病例正在增加,其中Candida albicans和Candida glabrata等特定物种最为普遍.
- 新兴的抗真菌耐药性需要仔细选择实证抗真菌疗法,以改善临床结果.
- 为了监测抗真菌敏感性模式,开发了一种机构抗真菌图.
研究的目的:
- 为了评估无菌场所Candida物种分离物的数量和类型.
- 评估常见的Candida物种的抗真菌敏感性模式.
- 为指导治疗创建一个机构的抗真菌图.
主要方法:
- 从2013年1月到2023年7月,对无菌部位的Candida分离物的回顾性图表审查.
- 收录标准:对常见的Candida物种 (C. albicans,C. glabrata,C. parapsilosis,C. krusei,C. tropicalis) 呈阳性的无菌部位培养.
- 排除标准:少于10个分离物或缺少敏感性数据.
主要成果:
- 分析了242个无菌部位的Candida分离物,其中90.1%来自成年患者.
- 最常见的物种是Candida albicans (54.5%),其次是Candida glabrata (30.6%).
- 确定并总结了每个物种的易感率.
结论:
- 局部抗真菌仪对于检测医疗保健系统内的抗真菌耐药性非常有价值.
- 抗真菌图可以指导选择适当的实证抗真菌疗法.
- 监测易感性模式对于管理侵入性Candida感染至关重要.
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