Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Targeting homologous recombination deficiency with intensified chemotherapy versus standard chemotherapy followed by olaparib in stage III breast cancer (SUBITO): an open-label, randomised, controlled, phase 3 trial.

The Lancet. Oncology·2026
Same author

Second Joint Annual Congress of the British Society of Toxicologic Pathology and the European Society of Toxicologic Pathology Special Issue.

Toxicologic pathology·2026
Same author

Spatiotemporal organisation of residual disease in mouse and human BRCA1-deficient mammary tumours and breast cancer.

Nature communications·2026
Same author

Nucleophagy removes cytotoxic trapped PARP1.

Nature cell biology·2026
Same author

Safety and activity of RO7300490, a bispecific CD40 agonist targeted to fibroblast activation protein, in patients with advanced solid tumors: a single-arm, multicenter, first-in-human, phase 1 trial.

Nature cancer·2026
Same author

FAP-Targeted LTBR Agonist Drives HEV Differentiation and Immune Niche Formation for Improved Immunotherapy Response in Solid Tumours.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same journal

Comparison of Standard Clinical Pathology Parameter Values in Fasted and Fed Rats and Non-human Primates.

Toxicologic pathology·2026
Same journal

Time-Dependent Autolysis in Ex Vivo-Maintained Rat Tissue in Saline: A Descriptive Study and Practical Guidance for Histopathologic Assessment.

Toxicologic pathology·2026
Same journal

New Approach Methodologies (NAMs) for Carcinogenicity Evaluation.

Toxicologic pathology·2026
Same journal

2025 International Academy of Toxicologic Pathology (IATP) Satellite Symposium: Pathology Working Groups (PWGs) in Toxicologic Pathology.

Toxicologic pathology·2026
Same journal

Toxicologic Pathology Forum*: Opportunities and Challenges in the Use of Artificial Intelligence in Nonclinical Toxicologic Histopathology Evaluations.

Toxicologic pathology·2026
Same journal

New Modalities and Carcinogenicity Assessment.

Toxicologic pathology·2026
查看所有相关文章

相关实验视频

Updated: May 21, 2025

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
09:19

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Published on: July 6, 2022

4.8K

迷你评论:空间转录学解码中枢神经系统

Benedek Pesti1,2, Xavi Langa1, Nadine Kumpesa1

  • 1Roche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland.

Toxicologic pathology
|March 22, 2025
PubMed
概括
此摘要是机器生成的。

空间转录学 (ST) 在中枢神经系统 (CNS) 中映射基因表达. 这项技术通过揭示分子机制和潜在的药物标来帮助神经退行性疾病研究.

关键词:
阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.帕金森病是帕金森氏症的一种疾病.骨髓缩性侧面硬化症 (ALS) 是一种疾病.中枢神经系统中枢神经系统多发性硬化症多发性硬化症神经退行性疾病的神经退行性疾病空间转录学 空间转录学

更多相关视频

Spatially Compact Arrangement of Larval Zebrafish Sections for Spatial Transcriptomic Analysis
07:40

Spatially Compact Arrangement of Larval Zebrafish Sections for Spatial Transcriptomic Analysis

Published on: May 16, 2025

49
Isolation of Region-specific Microglia from One Adult Mouse Brain Hemisphere for Deep Single-cell RNA Sequencing
09:49

Isolation of Region-specific Microglia from One Adult Mouse Brain Hemisphere for Deep Single-cell RNA Sequencing

Published on: December 3, 2019

10.7K

相关实验视频

Last Updated: May 21, 2025

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
09:19

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Published on: July 6, 2022

4.8K
Spatially Compact Arrangement of Larval Zebrafish Sections for Spatial Transcriptomic Analysis
07:40

Spatially Compact Arrangement of Larval Zebrafish Sections for Spatial Transcriptomic Analysis

Published on: May 16, 2025

49
Isolation of Region-specific Microglia from One Adult Mouse Brain Hemisphere for Deep Single-cell RNA Sequencing
09:49

Isolation of Region-specific Microglia from One Adult Mouse Brain Hemisphere for Deep Single-cell RNA Sequencing

Published on: December 3, 2019

10.7K

科学领域:

  • 神经科学是一个神经科学.
  • 基因组学就是基因组学.
  • 生物技术是生物技术.

背景情况:

  • 空间转录学 (ST) 提供空间解析的基因表达数据,彻底改变了中枢神经系统 (CNS) 研究.
  • 神经退行性疾病,如阿尔茨海默病,帕金森病,多发性硬化症和ALS是复杂的,并从先进的分子绘图中受益.

研究的目的:

  • 审查空间转录学在理解中枢神经系统疾病中的影响和应用.
  • 要突出ST如何通过将基因表达与组织架构相结合来推进神经退行性疾病的研究.

主要方法:

  • 基于测序和基于成像的基本空间转录组学技术的审查.
  • 对关键研究的分析,证明ST在将转录组映射到组织形态学和阐明疾病机制方面的实用性.

主要成果:

  • 在中枢神经系统疾病中,ST能够将基因表达映射到特定的组织结构和细胞脆弱性.
  • 单细胞数据与组织层面的映射的整合以及受体-连接体相互作用的识别是关键应用.
  • ST有助于理解神经退行症中的区域和细胞易感性.

结论:

  • 空间转录学为神经退行性疾病的分子基础提供了强大的洞察力.
  • ST有助于识别新的药物标,并评估中枢神经系统疾病的治疗策略.
  • 这项技术弥合了动物模型和人类研究之间的差距,以开发有效的中枢神经系统治疗方法.