甘油三,高密度脂蛋白和中年和老年人的认知功能:横截面分析
Lanying Xie1,2, Huanhuan Luo2,3, Yajie Zhao4
1School of Nursing, Beijing University of Chinese Medicine, Beijing, China.
Biogerontology
|March 22, 2025
概括
保持最佳的甘油三水平对于中国老年人的认知健康至关重要. 较低的高密度脂蛋白 (HDL) 水平与更好的认知功能有积极的关联,BMI调解了这一效应.
科学领域:
- 老年学是一门学科.
- 神经科学是一个神经科学.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 老龄化人口面临越来越多的认知衰退.
- 脂质代谢障碍在中国越来越令人担忧.
- 识别可修改的认知功能风险因素至关重要.
研究的目的:
- 研究中国成年人的甘油三 (TG),高密度脂蛋白 (HDL) 和认知表现之间的关系.
- 探索这些协会背后的潜在机制.
- 为了确定老年人认知健康的最佳脂质水平.
主要方法:
- 使用2015年中国健康与退休纵向研究 (CHARLS) 数据进行的横截面研究.
- 认知功能的评估 (全球认知,情节性记忆,精神状态).
- 使用限制立方脊柱 (RCS) 和多变量线性回归,分析空腹血液样本的TG和HDL水平,并对BMI进行中介分析.
主要成果:
- 在TG水平和全球认知/情节性记忆之间观察到一个反向的U形关系.
- 在HDL和认知结果之间没有发现显著的非线性关系.
- 与最高四分位数 (HDLQ4) 相比,较低的HDL水平 (HDL四分位数1-3) 与情节性记忆有积极的关联.
- "高-TG-低-HDL"组与"高-HDL-低-TG"组相比,对情节性记忆有显著的积极影响.
- 身体质量指数 (BMI) 调解了HDL和情节性记忆之间的关系,占影响的22.2%.
结论:
- 甘油三度与认知功能呈现U形反向关系,突出显示保持最佳甘油三度水平的重要性.
- 较低的HDL水平与更好的认知功能有关,特别是情节性记忆.
- 体重指数 (BMI) 在HDL和情节性记忆之间的关联中起着调解作用.
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