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来自Lactobacillus johnsonii的白血酸通过向CD36促进脂肪酸的吸收和沉积

Yunxia Li^1,2, Zhiming Zhang^1,2, Qi Han^1,2

¹College of Animal Science and Technology, Hunan Agriculture University, Changsha, 410128, China.

Science China. Life sciences

|March 22, 2025

概括

乳杆菌约翰尼 MS0621通过增加CD36表达来增强脂肪酸的吸收和沉积. 一种代谢物, (R) - 酸,调解了这种效应,提供了对肠道微生物群和脂质代谢的见解.

科学领域:

微生物学微生物学
胃肠病学胃肠病学
代谢过程中的代谢.

背景情况:

牛乳杆菌 johnsonii与脂质沉积有关,但其机制尚不清楚.
了解肠道微生物群在脂质代谢中的作用对于代谢健康至关重要.

研究的目的:

研究乳酸菌 (Lactobacillus johnsonii) MS0621促进脂肪酸的吸收和沉积的机制.
为了确定参与脂质调节的特定细菌代谢物.

主要方法:

从肥胖猪中分离和评估L. johnsonii MS0621的益生菌.
在体内和体外 (IPEC-J2细胞) 评估脂肪酸吸收和脂质沉积.
代谢分析,分子对接和CD36抑制研究.

主要成果:

在猪中,L. johnsonii MS0621殖民增加了肠道乳杆菌,脂肪酸吸收和脂质沉积.
活体细菌和超级生物促进了IPEC-J2细胞中的甘油三合成和CD36表达.
(R) - 叶酸被确定为一种向CD36的代谢物,调解脂质吸收.

结论:

L. johnsonii MS0621在调节肠道脂肪酸的吸收和沉积方面发挥着重要作用.
从L. johnsonii MS0621中获得的 (R) - 叶酸通过调节CD36表达来调节这个过程.
这项研究揭示了一种新的机制,将肠道细菌与宿主脂质代谢联系起来.

关键词:

在L. johnsoniiMS062121中发现.(R) - 白血酸的使用.吸收吸收吸收吸收脂肪酸脂肪酸是一种脂肪酸.

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