放射性隔离综合征:智利6年后续研究
Felipe Condeza1, Alicia Muñoz1, Carolina Pelayo1
1Neurology, Pontificia Universidad Católica de Chile, Santiago, Chile.
Multiple sclerosis and related disorders
|March 22, 2025
概括
放射性隔离综合征 (RIS) 不常见,但在无症状阶段早期使用疾病修饰疗法 (DMT) 治疗可能会改善结果并降低患多发性硬化症 (MS) 的风险.
科学领域:
- 神经学 神经学
- 神经免疫学 神经免疫学
- 放射学 放射学是一门学科.
背景情况:
- 放射性隔离综合征 (RIS) 是由符合多发性硬化症 (MS) 诊断标准的白质病变在没有临床症状的个体的特征.
- 疾病修饰疗法 (DMT) 已显示出在高风险人群中预防临床MS发展的潜力.
研究的目的:
- 确定被诊断患有RIS的患者的频率和长期临床结果.
- 评估DMT在RIS患者中的有效性.
主要方法:
- 在智利的一家多发性硬化转诊中心进行了一项观察性纵向研究 (后期和前期).
- 患者每六个月进行一次定期的MRI和临床评估.
- 评估结果包括临床转换,新的无症状MRI病变和没有疾病活动证据 (NEDA).
主要成果:
- 在3.3% (28/848) 的患者中发现了RIS,随访时间中位数为72个月.
- 25%的患者在21个月的中位数内发生了临床转化为MS.
- 在新的无症状病变后启动DMT的患者中,NEDA3被67%的患者实现,而在临床转换后启动的患者中,这一比例为43%.
结论:
- RIS是一种罕见的诊断,具有显著的临床转化率到MS.
- 在RIS无症状前期阶段早期开始使用DMT治疗与更好的结果有关.
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