植物化学物质具有整体作用,在家禽菌病期间增强宿主防御能力

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Updated: May 21, 2025

Nucleofection and In Vivo Propagation of Chicken Eimeria Parasites

Nucleofection and In Vivo Propagation of Chicken Eimeria Parasites

Published on: February 14, 2020

Inkyung Park¹, Hyoyoun Nam¹, Sripathy Ravichandran²

¹Animal Bioscience and Biotechnology Laboratory, United States Department of Agriculture, Beltsville Agricultural Research Center, Beltsville, MD 20705, USA.

Poultry science

|March 22, 2025

概括

用肉,丁香和香精油 (CCO) 补充食,改善了肉感染的肠道免疫力和完整性. 通过调节宿主反应,CCO增强了肠道健康并减少了体重减轻,而不是直接杀死病原体.

科学领域:

动物科学动物科学
免疫学免疫学免疫学
营养保健品营养保健品

背景情况:

菌病对肉的健康和生产力构成重大威胁.
植物化学物质为疾病管理提供了抗生素替代品的潜力.
了解宿主介导的反应对于开发有效的营养药策略至关重要.

研究的目的:

为了研究植物化学混合物 (肉,丁香,香精油 - CCO) 对肉生长,肠道免疫力和菌病期间的完整性的影响.
评估CCO对炎症标志物和肠道屏障功能的影响,在体外和体内.
为了确定CCO是否调节宿主反应,而不是对Eimeria maxima表现出直接的抗菌活性.

主要方法:

在CCO刺激后使用巨细胞 (CMC) 和肠上皮细胞 (IEC) 进行体外研究,以评估炎症基因表达 (IL-1β,IL-8) 和肠壁蛋白 (occludin,ZO-1,MUC2).
在体内实验中,用感染Eimeria maxima的肉进行实验,比较基底饮食 (PC) 与补充CCO (4.5 mg/kg) 的饮食.
测量身体重量,细胞因子,紧结蛋白和抗氧化酶的状基因表达;卵囊数量也被评估.

主要成果:

CCO显著降低了CMC中的IL-1β和IL-8表达,并以剂量依赖的方式增加了IEC中的ZO-1和MUC2表达.
饮食中CCO补充剂倾向于减轻受感染肉的体重减轻和抑制促炎细胞因子.
CCO增加了阴中的奥克卢丁和JAM-2表达,但并没有减少Eimeria卵的数量.

结论:

饮食中CCO补充剂增强了Eimeriamaxima感染肉的肠道免疫力和完整性.
CCO的好处似乎源于调节宿主生理反应,改善肠道屏障功能和减少炎症.
这项研究强调了体外查宿主介导作用的价值,用于识别用于禽类疾病缓解的植物化学物质.

关键词:

肉肉肉肉肉肉肉肉肉肉肉肉肉肉肉肉肉肉肉肉肉肉肉肉肉肉肉肉肉肉肉肉肉肉肉肉肉肉肉肉肉肉肉肉肉肉肉肉肉肉肉肉肉肉肉肉肉肉肉肉肉肉菌病是一种菌病.精油精油精油精油肠道健康肠道健康植物化学品植物化学品

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