多种环境空气污染物,遗传风险和发生精神障碍之间的关联:英国人口的相互作用研究
Xiaoxin I Yao1, Shengzhi Sun2, Qian Yang3
1Department of Orthopaedics, The Eighth Affiliated Hospital, Sun Yat-Sen University, PR China; Department of Clinical Research, The Eighth Affiliated Hospital, Sun Yat-sen University, PR China.
The Science of the total environment
|March 22, 2025
概括
长期暴露于空气污染,包括细颗粒物 (PM2.5) 和氧化 (NOx),增加患上抑郁症,焦虑症和精神分裂症等精神障碍的风险. 遗传易感性并没有改变这些关联.
科学领域:
- 环境健康 环境健康
- 精神病学是一个精神病学.
- 流行病学 流行病学
背景情况:
- 精神疾病是由遗传和环境因素引起的.
- 关于长期暴露于空气污染和心理健康的研究有限,通常专注于单一的污染物.
- 了解这些联系对于公共卫生倡议至关重要.
研究的目的:
- 调查长期暴露于多种空气污染物和新发精神障碍之间的关联.
- 探索遗传易感性是否影响空气污染和心理健康结果之间的关系.
- 评估抑郁症,焦虑症和精神分裂症的风险.
主要方法:
- 利用了来自252,376名参与者的英国生物库数据 (2006-2022年).
- 采用考克斯回归来分析各种空气污染物 (PM2.5吸收率,PM2.5,PM2.5-10,PM10,NO2,NOx) 和精神障碍之间的相关性.
- 研究了空气污染与精神疾病多基因风险评分 (PRS) 之间的相互作用.
主要成果:
- 增加对PM2.5吸收率,PM2.5,NO2和NOx的暴露与发生精神障碍的风险更高相关.
- 空气污染得分增加与精神疾病风险增加6%,精神分裂症风险增加24%,抑郁症风险增加4%,焦虑症风险增加6%.
- 在空气污染暴露和精神分裂症,抑郁症或焦虑症遗传风险得分之间没有发现显著的相互作用.
结论:
- 长期暴露于常见的空气污染物与患精神疾病的风险增加有关.
- 空气污染控制措施对于减少全球心理健康状况负担至关重要.
- 遗传因素似乎没有改变空气污染对研究精神障碍的影响.
相关概念视频
Human Genetics
506
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
506
Gene-Environment Interactions
228
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
228
Cancer Prevention
6.0K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.0K
Stress and Mental Health
67
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Individuals with depression often experience challenges in both their personal and professional...
67
Background and Environment Affect Phenotype
6.4K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
6.4K
Behavioral Genetics and Its Designs
308
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
308


