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Updated: May 21, 2025

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设计,合成和评估新型卡博林-三混合物作为有前途的抗疟疾药物

Ajay Kishor Kushawaha1, Rohini Nandi2, Arvind Kumar Jaiswal1

  • 1Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute BS, 10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow, 226031, Uttar Pradesh, India.

European journal of medicinal chemistry
|March 22, 2025
PubMed
概括

新的卡博林-三醇化合物显示出强大的抗疟疾活性,对抗虫寄生虫. 化合物15k在体内表现出强烈的疗效和有利的药理动力学,这表明口服药物开发的潜力.

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Aryldiazonium Salts to Azo Dyes: Diazo Coupling01:11

Aryldiazonium Salts to Azo Dyes: Diazo Coupling

The reaction of weakly electrophilic aryldiazonium (also called arenediazonium) salts with highly activated aromatic compounds leads to the formation of products with an —N=N— link, called an azo linkage. This reaction, presented in Figure 1, is known as diazo coupling and occurs without the loss of the nitrogen atoms of the aryldiazonium salt. Highly activated aromatic compounds such as phenols or arylamines favor the diazo coupling reaction. The coupling generally occurs at the...
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