周围神经侵入和淋巴结比率四分位数与口腔腔状细胞癌的外节延伸有关
Piper A Wenzel1, Steven L Van Meeteren1, Nitin A Pagedar2
1Medical Student, Carver College of Medicine, University of Iowa, Iowa City, IA.
概括
瘤特征如围神经侵入 (PNI) 和淋巴结比率 (LNR) 与口腔皮细胞癌 (OCSCC) 的外节延伸 (ENE) 有关. 这一发现有助于为OCSCC患者进行手术前咨询和治疗计划.
科学领域:
- 在瘤学瘤学.
- 头部和部手术 头部和部手术
- 病理学 病理学 病理学
背景情况:
- 在口腔状细胞癌 (OCSCC) 中,外节延伸 (ENE) 很难在手术前进行评估.
- 确定原发性瘤特征和ENE之间的相关性可以改善患者咨询和辅助治疗计划.
研究的目的:
- 确定病理性瘤特征与OCSCC患者中ENE的存在之间的关联.
主要方法:
- 对233名接受治疗性手术的OCSCC患者进行了回顾性队列研究 (2004-2018).
- 评估瘤特征,包括亚部位,T分类,围神经侵入 (PNI),淋巴血管侵入,骨侵入和淋巴结比率 (LNR).
- 使用双变量和多变量逻辑回归来分析与ENE状态的相关性.
主要成果:
- 超过一半 (52.4%) 的结节转移患者患有ENE.
- 双变量分析显示了ENE和PNI,骨侵袭,LNR四分位数和病理T类之间的显著相关性.
- 多变量分析证实PNI (OR=2.29) 和LNR四分位数 (P<.001) 作为ENE的显著预测因素.
结论:
- PNI和高LNR是OCSCC中ENE的重要预测因素.
- 这些发现可以加强手术前的患者咨询,并为辅助治疗策略提供信息,特别是在手术前没有明显的ENE的患者.
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