Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Gastrulation01:56

Gastrulation

55.7K
Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
55.7K
Mechanism of Lamellipodia Formation01:31

Mechanism of Lamellipodia Formation

2.5K
Cells migrating in response to external stimuli form lamellipodia, which are thin membrane protrusions supported by a mesh of linked, branched, or unbranched actin filaments. These actin filaments interact with myosin motor proteins, creating the dynamic actomyosin complex within the cytoskeleton. Contractility, or the ability to generate contractile stress, is inherent to the actomyosin complex. It helps cells detect the stiffness of the surrounding ECM and exert contractile force for...
2.5K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Genetically engineered ESC-derived embryos reveal Vinculin-dependent force responses required for mammalian neural tube closure.

bioRxiv : the preprint server for biology·2026
Same author

A single-cell atlas of spatial and temporal gene expression in the mouse cranial neural plate.

eLife·2025
Same author

Actin crosslinking is required for force sensing at tricellular junctions.

bioRxiv : the preprint server for biology·2025
Same author

A single-cell atlas of spatial and temporal gene expression in the mouse cranial neural plate.

bioRxiv : the preprint server for biology·2024
Same author

Torques within and outside the human spindle balance twist at anaphase.

The Journal of cell biology·2024
Same author

The oncogene cyclin D1 promotes bipolar spindle integrity under compressive force.

PloS one·2024
Same journal

Estetrol potentiates progesterone-driven growth restraint while blunting pro-angiogenic activation in murine endometriosis lesions.

Cells & development·2026
Same journal

Transcriptomic signatures and neural cell composition in schizophrenia iPSC-derived neuron cultures.

Cells & development·2026
Same journal

Upregulation of adenylyl cyclase 1 is crucial for osteogenic and adipogenic differentiation of MSCs.

Cells & development·2026
Same journal

Toll-like receptors in epithelial mechanics and surveillance.

Cells & development·2026
Same journal

Functions and mechanisms of BRCA1 in early embryonic development.

Cells & development·2026
Same journal

The face you're born with: How early development dictates a lifetime of expression and ageing.

Cells & development·2026
查看所有相关文章

相关实验视频

Updated: May 21, 2025

Engineering Three-dimensional Epithelial Tissues Embedded within Extracellular Matrix
08:49

Engineering Three-dimensional Epithelial Tissues Embedded within Extracellular Matrix

Published on: July 10, 2016

7.5K

在上皮形成中的三维红.

Lila Neahring1, Jennifer A Zallen1

  • 1HHMI and Developmental Biology Program, Sloan Kettering Institute, New York, NY, United States of America.

Cells & development
|March 22, 2025
PubMed
概括
此摘要是机器生成的。

多细胞红是构建上皮组织的关键. 这些结构协调细胞行为,使各种组织结构的形成成为发展和疾病理解的必要条件.

关键词:
角 - 基底极度的极度.细胞粘附 细胞粘附皮质形态发生的表皮形态发生.这就是光源生成 (Lumenogenesis).中介细胞-上皮细胞过渡.线粒素的收缩性 线粒素的收缩性罗塞特 (Rosette) 是一个红.

更多相关视频

Robust and Highly Reproducible Generation of Cortical Brain Organoids for Modelling Brain Neuronal Senescence In Vitro
05:40

Robust and Highly Reproducible Generation of Cortical Brain Organoids for Modelling Brain Neuronal Senescence In Vitro

Published on: May 5, 2022

3.7K
2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development
14:19

2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development

Published on: March 25, 2022

3.8K

相关实验视频

Last Updated: May 21, 2025

Engineering Three-dimensional Epithelial Tissues Embedded within Extracellular Matrix
08:49

Engineering Three-dimensional Epithelial Tissues Embedded within Extracellular Matrix

Published on: July 10, 2016

7.5K
Robust and Highly Reproducible Generation of Cortical Brain Organoids for Modelling Brain Neuronal Senescence In Vitro
05:40

Robust and Highly Reproducible Generation of Cortical Brain Organoids for Modelling Brain Neuronal Senescence In Vitro

Published on: May 5, 2022

3.7K
2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development
14:19

2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development

Published on: March 25, 2022

3.8K

科学领域:

  • 发展生物学 发展生物学
  • 细胞生物学 细胞生物学
  • 组织工程是组织工程.

背景情况:

  • 表皮组织执行重要的结构,信号和屏障功能.
  • 了解个体细胞如何形成集体上皮质结构是一个关键的发育生物学问题.
  • 多细胞红正在成为表皮组织形成的关键中间体.

研究的目的:

  • 审查调节罗塞特组装和动态的机制.
  • 讨论罗塞特作为多功能中间体在表皮形态发生过程中的作用.
  • 突出罗塞特生物学的开放问题及其对发育和疾病的影响.

主要方法:

  • 关于多细胞红的最近研究的文献综述.
  • 分析控制罗塞特形成和行为的细胞和分子机制.
  • 讨论了罗塞特动态的基础上的生物物理原理.

主要成果:

  • 辐射偏振的粉丝圈为细胞提供了一个受保护的环境,以发展极性和粘附.
  • 红会动态扩展,移动和凝聚,从而产生各种表皮结构.
  • 罗塞特对于形成上皮层,管道,腔和分支网络至关重要.

结论:

  • 多细胞红对于协调细胞相互作用和构建复杂的上皮组织至关重要.
  • 罗塞特动态对于胚胎发育过程中的多种形态遗传过程至关重要.
  • 对罗塞特机制的进一步研究可以阐明胚胎发育和人类疾病.