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与产前暴露于排气管和非排气管颗粒物污染相关的自闭症风险的不一致的兄弟分析

Anny H Xiang¹, Jane C Lin¹, Ting Chow¹

¹Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, CA, USA.

Environmental research

|March 22, 2025

概括

产前暴露于铜,铁和等非尾管交通污染物与增加自闭症谱系障碍 (ASD) 风险有关. 这些关联,在怀孕早期特别强烈,加强了因果关系的证据.

科学领域:

环境流行病学环境流行病学
发育毒理学发展毒理学
自闭症谱系障碍研究研究

背景情况:

之前的研究将产前细颗粒物 (PM2.5) 标志物与自闭症谱系障碍 (ASD) 风险联系起来.
遗传和家庭环境因素可能会混这些关联.
使用ASD异调的兄弟研究设计来解决混问题.

研究的目的:

评估产前暴露于特定与交通有关的空气污染物和ASD风险之间的关联.
调查排气管 (元素碳,有机碳) 与非排气管 (铜,铁,) 排放的作用.
用兄弟研究设计来确认先前的发现,以控制共享的遗传和环境因素.

主要方法:

利用了来自1801名母亲的4024名儿童 (1837名有自闭症,2187名没有) 的数据.
评估产前暴露于PM2.5,微量元素 (Cu,Fe,Mn),EC,OC和近路空气污染 (NRAP) 的情况.
采用条件后勤回归,对共变量进行调整,并将结果报告为每四分位数间增量的赔率比率 (OR).

主要成果:

孕期暴露于非排气管污染物铜 (OR 1.17),铁 (OR 1.26) 和 (OR 1.29) 与ASD风险增加有关.
排气管污染物元素碳和有机碳与ASD风险没有显著的关联.
在调整为PM2.5或NRAP后,与非尾管污染物的关联仍然很重要,并且在前两个季度最为明显.

结论:

与ASD不一致的兄弟研究证实了产前暴露于PM2.5,NRAP和非尾管微量元素 (Cu,Fe,Mn) 与ASD风险之间的关联.
研究结果表明,在怀孕的前两个季度,特别容易受到伤害.
结果提供了更多的证据支持这些特定的产前暴露和ASD之间的因果关系.

关键词:

自闭症自闭症自闭症不和的兄弟分析分析.没有尾管的非尾管构成PM的组成部分 ((2.5)).尾管尾管尾管尾管是一个

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