功能障碍的呼吸和抑郁是2型高度严重喘的核心肺外和行为/危险因素特征
Yuto Hamada1, Peter G Gibson2, Vanessa L Clark3
1Center of Excellence in Treatable Traits, College of Health, Medicine and Wellbeing, the University of Newcastle, New Lambton Heights, NSW, Australia; Asthma and Breathing Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia; Clinical Research Center for Allergy and Rheumatology, NHO Sagamihara National Hospital, Sagamihara, Japan.
在高2型炎症的严重喘中,功能障碍的呼吸和抑郁是影响结果的关键特征. 识别这些可治疗的特征可以改善喘管理,减少全身炎症.
科学领域:
- 肺部医学 肺部医学
- 精神病体医学是一种精神病体医学.
- 炎症研究 炎症研究
背景情况:
- 肥胖和吸烟已成为2型 (T2) 低喘中可治疗的特征.
- 然而,T2高喘的核心肺外和行为风险因子特征仍然不太了解.
研究的目的:
- 确定T2高严重喘中的关键肺外和行为/风险因素特征.
- 了解这些特征与喘控制,生活质量和恶化之间的关系.
主要方法:
- 一项对187名严重喘患者 (≥18岁) 的横截面研究,使用多维评估.
- 高T2喘是由血中乙酸氨基细胞 (≥150细胞/μL) 和/或部分排出的氧化 (≥20ppb) 定义的.
- 网络和主导分析确定了影响喘结果和生物标志物的核心特征.
主要成果:
- 151名 (80.7%) 参与者患有T2高的严重喘.
- 功能障碍的呼吸和抑郁症成为主要的TT,与更糟糕的喘控制,生活质量和恶化有很强的联系.
- 这些特征与系统性炎症 (中性粒细胞,中性粒细胞-淋巴细胞比率,hs-CRP) 的增加相关,不论是肥胖,口服皮质类固醇使用或焦虑.
结论:
- 功能障碍的呼吸和抑郁症被确定为T2高严重喘的核心肺外和行为特征.
- 这些特征显著恶化了喘结果,突出了喘表型之间的TT差异.
- 升高的全身炎症可能是识别这个患者群体中功能障碍呼吸和抑郁症的指标.
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