相关实验视频
Updated: May 21, 2025

10:32
Development of a Virtual Reality Assessment of Everyday Living Skills
Published on: April 23, 2014
18.3K
对精神分裂症谱系障碍的声学生物标志物及其与症状和认知功能相关的关联
Kangwook Jang1, Ling Li2, Thi-Hung Le2
1School of Electrical Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
Progress in neuro-psychopharmacology & biological psychiatry
|March 22, 2025
概括
使用机器学习的声学分析可以准确地识别精神分裂症谱系障碍 (SSD) 和认知缺陷. 主要的语音特征与SSD患者的注意力和记忆相关.
科学领域:
- 神经科学是一个神经科学.
- 计算精神病学是一种计算精神病学.
- 语音科学 语言科学
背景情况:
- 精神分裂症谱系障碍 (SSD) 通常涉及情绪处理缺陷.
- 声学生物标志物提供了一种非侵入性,客观的方法来评估这些损伤.
- 机器学习 (ML) 模型可以分析诊断潜力的复杂语音模式.
研究的目的:
- 评估ML模型在对SSD与健康对照 (HC) 个人进行分类时的准确性.
- 在SSD中区分认知缺陷 (Cog-D) 和认知非缺陷 (Cog-ND) 亚型.
- 探索声学特征与临床/认知措施之间的相关性.
主要方法:
- 从238名SSD患者和157名HC在各种任务中收集的语音数据.
- 使用openSMILE工具包提取的声学特征;经过10倍交叉验证训练的模型.
- 调整为药物效应 (ESRS,CPZ) 的部分相关性分析探索了特征-症状关系.
主要成果:
- 支持矢量机 (SVM) 实现了最高的准确性:SSD与HC的83% (所有任务),85% (快乐句子任务).
- 对Cog-D和HC的SVM准确率为79% (言论自由/快乐句子);SSD内部的分类 (Cog-D和Cog-ND) 很差.
- 顶尖的声学特征与SSD患者的注意力和口头记忆有显著的相关性.
结论:
- 用ML驱动的声学分析显示了对SSD和Cog-D亚型与HC分类的希望.
- 音调,音响和音色特征与SSD中的注意力缺陷有着显著的联系.
- 未来的研究应该调查声学生物标志物用于多类分类,治疗反应和复发检测.
相关概念视频
Negative and Cognitive Symptoms of Schizophrenia
39
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
39
Biological Causes of Schizophrenia
29
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
29
Positive Symptoms of Schizophrenia: Hallucinations and Delusions
47
Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
47
Psychological and Sociocultural Causes of Schizophrenia
41
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
41
Schizophrenia
50
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
50
Positive Symptoms Schizophrenia: Hallucinations and Delusions
40
Schizophrenia is a complex psychiatric disorder characterized by a range of symptoms that significantly impact cognition, behavior, and emotional regulation. Among these, the positive symptoms stand out as they involve the addition or exaggeration of normal mental functions, deviating markedly from typical behavior and perception. Hallucinations and delusions are prominent positive symptoms, each profoundly affecting the individual's experience of reality.
Hallucinations
Hallucinations in...
Hallucinations
Hallucinations in...
40

