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甘二甲基乙烯交叉链接剂对粉混合药用薄膜的作用

Rodrigo Alberto do Nascimento¹, Denise Tiemi Uchida¹, Rodolfo Bento Balbinot²

¹Laboratory of Research and Development of Drug Delivery Systems, Postgraduate Program in Pharmaceutical Sciences, Department of Pharmacy, State University of Maringa, Av. Colombo 5790, 87020-900 Maringa, Parana, Brazil.

International journal of biological macromolecules

|March 22, 2025

概括

糖二甲基乙醇 (GDE) 交联增强了点粉制药薄膜,提高了机械强度,并证明了pH取决于水的吸收. 这些非细胞毒性薄膜对制药应用有前途.

科学领域:

材料科学材料科学材料科学
聚合物化学聚合物化学
制药技术制药技术制药技术

背景情况:

制药薄膜需要多功能和生物相容的材料.
素和粉混合物提供了潜力,但需要性能增强.
甘二甲基乙烯 (GDE) 是一种用于改进多糖基材料的交联剂.

研究的目的:

开发和描述与GDE交联的粉膜.
评估GDE交联对薄膜物理化学性质的影响.
评估这些薄膜在制药应用中的潜力.

主要方法:

使用溶剂蒸发制成的薄膜,含有不同度的pectin,粉和GDE.
优化总固体度 (5.0%) 和干燥温度 (35°C).
综合性表征包括ATR-FTIR,TGA,DSC,拉力测试,膨胀能力,水蒸气透性,SEM和体外细胞毒性测试.

主要成果:

交叉连接的薄膜的厚度为0.1420.150毫米.
ATR-FTIR证实了多糖和GDE之间可能的交叉链接.
在GDE交叉连接的薄膜中观察到更好的热稳定性和机械强度.
膜显示了pH值依赖的胀,在中性pH值时吸收率更高,并且具有均的多孔结构.
在体外细胞毒性测试显示,对测试的细胞系没有任何不良影响.

结论:

GDE有效地交叉链接点氨酸-粉混合物,增强薄膜特性.
开发的薄膜具有药物使用的理想特征.
与GDE交联的点丁粉薄膜代表了制药应用的有希望的,创新的替代方案.

关键词:

交叉连接 (crosslinking) 是一种连接方式.电影电影电影电影机械性质机械性质质素 (Pectin) 是一种可怕的物质.粉是一种粉.

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