在rumenofaecobiome中揭开AMR动态:对于One Health的见解,挑战和影响
Ziming Wu1, Mustasim Famous2, Theano Stoikidou1
1School of Biological Science, Institute for Global Food Security, Queen's University Belfast, Belfast, UK.
International journal of antimicrobial agents
|March 22, 2025
概括
牲畜中的抗菌素耐药性 (AMR) 是一个全球性的威胁. 研究体和便的微生物,该研究的研究人员.
科学领域:
- 微生物学 微生物学
- 兽医科学 兽医科学 兽医科学
- 环境健康 环境健康
背景情况:
- 抗菌素耐药性 (AMR) 是一个关键的全球威胁,由移动遗传元素的横向基因转移 (HGT) 恶化.
- 目前对反动物的抗菌耐药性的研究往往使用菌生物组作为菌微生物组的代理,或专注于可培养的细菌,忽视不可培养的微生物.
- 无法培养的微生物种群可能会显著影响皮抗体和AMR动态,影响One Health战略.
研究的目的:
- 审查目前关于牲畜,特别是反动物中AMR负担的研究.
- 解决了解无法培养的微生物在乳头抗体中的作用的差距.
- 提出一种结合方法,研究体和体生物群 (rumenofaecobiome),以加强抗菌耐药性风险评估.
主要方法:
- 对牲畜中AMR现有文献的审查,重点关注反动物.
- 讨论肠微生物组和AMR传播的复杂性.
- 关于AMR传播动态和风险评估方法的总结.
主要成果:
- 在反动物中,可培养的反动物细菌含有具有HGT潜力的AMR基因.
- 现有的研究存在局限性,因为它们忽略了无法培养的微生物群.
- 建议采用"菌生物组"的方法,以更好地了解抗药性耐药性风险.
结论:
- 为了全面了解反动物中的AMR,需要研究反动物和便微生物组.
- "鲁门菌生物组"概念提供了一种更全面的方法来评估牲畜中AMR风险.
- 在One Health框架内,需要进一步研究抗药性对肠微生物群的影响.
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