与短期和长期存活相关的因素 消化管囊与气管消化管囊的食道
Joseph R Davidson1, Ahmed Refaat Khodary2, Aiysha Puri3
1Specialist Neonatal and Paediatric Surgery Department, Great Ormond Street Hospital, London, UK; Department of Paediatric Surgery, Evelina Children Hospital, Guy's and St Thomas NHS Trust, London, UK; UCL Great Ormond Street Institute of Child Health, London, UK.
Journal of pediatric surgery
|March 22, 2025
概括
一个新的食管风险 (OAR) 评分预测了患有OA-TOF的婴儿的生存率. 低出生体重和心脏问题增加了早期死亡率,而脏疾病和异常影响了长期生存率.
科学领域:
- 儿科手术 儿科手术
- 新生儿医学 新生儿医学
- 医学统计 医学统计
背景情况:
- 带有轨道食管的食管缩症 (OA-TOF) 需要准确的生存预测.
- 由于单个中心的起源,现有的风险评分可能缺乏外部有效性.
- 一个国际性的多中心队列被用来开发和验证OA-TOF.的新风险评分.
研究的目的:
- 为了模拟OA-TOF患者的生存率.
- 使用全球患者数据集验证新型风险评分.
- 确定OA-TOF中早期和长期死亡率的关键决定因素.
主要方法:
- 从4个高等教育中心 (2000-2022) 的数据回顾分析.
- 开发一个多变量后勤回归模型用于医院生存.
- 验证使用引导和考克斯回归来进行长期生存分析.
主要成果:
- 排放后的整体存活率为94%.
- 早期死亡率的预测因素包括出生体重较低,主要的心脏病变以及其他结构异常/综合征.
- 长期死亡率与主要的病和额外的主要结构异常/综合征有关.
结论:
- 患有OA-TOF和低出生体重或心脏病的婴儿面临更高的早期死亡风险.
- 主要的病和结构异常/综合征是整个死亡率的重要预测因素.
- 为了改善风险分层,提出了一个新的食管风险 (OAR) 评分.
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