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乳腺癌新辅助化疗后,身体活动和功能能力下降
Clarice Gomes Chagas Teodózio1, Thamyres Vitória Francisco da Silva Correia Gomes1, Louise Acalantis Pereira Pires Fernandes1
1Instituto Nacional do Câncer, Rio de Janeiro, Brazil.
BMJ supportive & palliative care
|March 22, 2025
概括
乳腺癌患者的新辅助化疗导致身体活动 (PA) 和手握强度降低. 然而,有氧能力和下肢抵抗力在治疗后保持不变.
科学领域:
- 在瘤学瘤学.
- 运动生理学 运动生理学
- 癌症康复 癌症康复
背景情况:
- 新辅助化疗是乳腺癌的标准治疗方法.
- 评估化疗对患者身体功能的影响对于支持性护理至关重要.
研究的目的:
- 评估乳腺癌患者在新辅助化疗前后的身体活动 (PA) 和功能能力的变化.
- 为了确定受这种治疗方案影响的特定物理参数.
主要方法:
- 一项前性队列研究,涉及440名接受乳腺癌新辅助化疗的妇女.
- 评估自我报告的PA水平和体力测试,包括握手力,坐立,静止行走等.
- 使用威尔科克森试验比较化疗前后的数据.
主要成果:
- 在化疗后观察到体力活动 (PA) 水平和手握强度的显著下降 (p<0.002).
- 没有发现有氧能力或下肢抵抗力的显著变化 (分别p=0.595和p=0.163).
- 研究群体主要由患有晚期乳腺癌的女性组成.
结论:
- 新辅助化疗对乳腺癌患者的身体活动和手握强度产生负面影响.
- 在这个队列中,有氧能力和下肢功能似乎对新辅助化疗有弹性.
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