接种SARS-CoV-2疫苗可以降低严重COVID-19中血栓性并发症的风险
M Ángeles Alonso Fernández1, Carola Bledig2, Madian Manso Álvarez1
1Hospital Universitario del Tajo, Critical Care Department, Universidad Alfonso X El Sabio, Spain.
Medicina intensiva
|March 22, 2025
概括
接种COVID-19疫苗显著降低了需要重症监护的严重病例中的血栓事件和死亡率. 未接种疫苗的患者面临这些并发症和死亡的更高风险,尽管血栓事件没有直接影响ICU死亡率.
科学领域:
- 关键护理医学 关键护理医学
- 传染性疾病 传染性疾病
- 心血管研究研究心血管研究
背景情况:
- 严重的COVID-19肺炎经常导致重症监护室 (ICU) 的入院.
- 血栓性并发症是重症COVID-19患者的一个重大问题.
- 在减轻这些风险方面,SARS-CoV-2疫苗的作用需要进一步调查.
研究的目的:
- 评估SARS-CoV-2疫苗接种与严重COVID-19患者的血栓事件之间的关联.
- 评估疫苗接种对ICU环境中的死亡率的影响.
- 为了确定血栓并发症是否影响ICU死亡率.
主要方法:
- 这是一项前性多中心观察性研究,涉及255名患者.
- 从五所大学医院的重症监护病房收集的数据.
- 关键变量包括SARS-CoV-2疫苗接种状态和血栓事件的发生.
主要成果:
- 在患有严重COVID-19肺炎的ICU患者中,有18.8%接种了疫苗.
- 血栓事件发生在21.2%的研究队列中.
- 缺乏疫苗接种与血栓事件 (OR 5.024) 和死亡 (OR 5.161) 的风险增加显著相关.
结论:
- 接种SARS-CoV-2疫苗与重症COVID-19患者血栓事件和死亡率降低的风险有关.
- 疫苗接种似乎是预防ICU中严重结局的保护因素.
- 血栓性并发症虽然与未接种疫苗相关,但在这个队列中并没有独立影响ICU死亡率.
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