糖尿病是心脏代谢指数和胆结石之间的缺失环节:一项大型横截面研究
Yu Zhang1, Xiangqian Gu2, Hua Lv3
1Department of Gastrointestinal Surgery, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi Medical Center, Wuxi, Jiangsu, China.
Scientific reports
|March 23, 2025
概括
更高的心脏代谢指数 (CMI) 与增加胆结石 (GS) 风险有关. 糖尿病显著调解了这种关联,建议在预防GS时共同管理血糖和脂质.
科学领域:
- 心脏病学 心脏病学
- 代谢障碍 代谢障碍 代谢障碍
- 胃肠病学 胃肠病学
背景情况:
- 心脏代谢指数 (CMI) 是心血管和代谢疾病的新型预测指标.
- 它与胆结石 (GS) 患病率和糖尿病中介作用的关联仍未得到充分探索.
研究的目的:
- 调查美国成年人中CMI水平和GS患病率之间的关系.
- 评估糖尿病对CMI-GS协会的调解作用.
- 为糖尿病患者早期预防和查GS的策略提供信息.
主要方法:
- 利用了2017-2020年国家健康和营养检查调查 (NHANES) 的数据.
- 采用横截面分析,物流回归,倾向得分匹配和受限制的立方线.
- 进行调解分析以量化糖尿病的作用.
主要成果:
- 在CMI升高和GS患病率增加之间发现了显著的正相关性.
- 每个单位的日志转换CMI增加与GS患病率上升23%相关 (完全纠正的模型).
- 糖尿病调解了CMI和GS之间的关系的15.1%.
结论:
- 较高的CMI水平与患胆结石的风险更高有关.
- 糖尿病在CMI和胆结石之间的病变发生过程中起着重要的调解作用.
- 脱脂症和血糖的综合管理可能会降低胆结石风险.
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