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Updated: May 21, 2025

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies
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A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies

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功能组合精准医学用于预测和优化软组织肉瘤治疗方法

Sharon Pei Yi Chan1, Masturah Bte Mohd Abdul Rashid2, Jhin Jieh Lim2

  • 1Cancer Science Institute of Singapore, National University of Singapore, 14 Medical Drive, #12-01 Centre for Translational Medicine, Singapore, 117599, Republic of Singapore.

NPJ precision oncology
|March 23, 2025
PubMed
概括

这项研究表明,正方形表型优化平台 (QPOP) 可以预测软组织肉瘤 (STS) 治疗反应. QPOP确定了一种新型药物组合,对STS患者具有更高的疗效.

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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