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确定RNA处理因子LSM5作为鼻癌中新的不良生物标志物

Ting Lin^1,2, Linyu Deng³, Siyu Liu⁴

¹Hunan Provincial Engineering Research Center for Prevention and Treatment of Ophthalmology and Otolaryngology Diseases With Chinese Medicine and Visual Function Protection, Hunan University of Chinese Medicine, No. 300, Xuba Road, Hanpu Science and Education Park, Changsha, 410208, Hunan, People's Republic of China.

Scientific reports

|March 23, 2025

概括

这项研究确定LSM5是鼻癌 (NPC) 进展中的关键RNA处理基因. 过度表达LSM5与预后不佳相关,并影响化疗敏感性,这表明它是NPC的潜在治疗标.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物信息学是一种生物信息学.

背景情况:

不调节的RNA处理显著影响鼻癌 (NPC) 的进展.
识别关键的RNA处理基因 (RPG) 对于理解NPC发育和改善患者的治疗结果至关重要.

研究的目的:

通过生物信息分析评估RPGs在NPC中的预后价值.
开发和验证基于RPG的NPC预测模型.
调查NPC中风险得分,免疫特征和化疗敏感性之间的相关性.

主要方法:

对GSE12452和GSE102349数据集的生物信息分析,以确定差异表达的RNA处理基因 (DE-RPG).
单变量和多变量考克斯回归和ROC分析用于预后模型开发和验证.
实验验证包括RT-qPCR,西部Blot,免疫组织化学和功能分析.

主要成果:

确定了RNA结合基因蛋白20 (RBM20) 和LSM5作为预后RPG.
一个预后模型证明了NPC存活的预测能力.
在NPC组织中LSM5的过度表达与更差的预后相关,其下调抑制了细胞增殖和迁移.
在高风险和低风险组之间观察到药物敏感性的显著差异.

结论:

LSM5被确定为鼻癌中的新型不良预后生物标志物.
LSM5在NPC的进展,扩散和迁移中发挥着作用.
准LSM5可能为改善NPC预后提供新的治疗策略.

关键词:

在LSM5中,LSM5是什么?鼻癌是指鼻癌.预测的签名预测的签名在RBM20中使用RBM20 处理RNA的基因.

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相关概念视频

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...