帕金森病中的呼吸障碍和呼吸障碍:患者报告的患病率和决定因素
Veerle A van de Wetering-van Dongen1, Maarten J Nijkrake2, Philip J van der Wees3
1Department of Rehabilitation, Center of Expertise for Parkinson and Movement Disorders, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, 6500 HB, P.O. Box 9101 (internal code 898), Nijmegen, The Netherlands. veerle.vandewetering-vandongen@radboudumc.nl.
Journal of neurology
|March 23, 2025
概括
呼吸功能障碍,包括呼吸不全和咳障碍,影响44%的帕金森病患者.
科学领域:
- 神经学 神经学
- 呼吸系统医学 呼吸系统医学
- 公共卫生 公共卫生
背景情况:
- 呼吸功能障碍是帕金森病 (PD) 的一个鲜为人知的并发症.
- 识别导致呼吸系统问题的因素对于早期发现和治疗PD患者至关重要.
研究的目的:
- 确定帕金森病 (PD) 患者自我报告的呼吸功能障碍症状的患病率.
- 在PD患者群体中调查与呼吸功能障碍相关的关键因素.
主要方法:
- 一项涉及939名患有PD的参与者进行的横截面研究,他们填写了问卷.
- 呼吸功能障碍是由呼吸困难,咳或胸部紧张等症状定义的.
- 主要组件分析 (PCA) 确定了"呼吸障碍"和"咳障碍"的构造;多变量逻辑回归分析了决定性关联.
主要成果:
- 在患有PD的人中,呼吸功能障碍的患病率为44% (42%不包括肺部疾病或COVID-19).
- PCA将"呼吸障碍"和"dystussia"确定为关键构造,解释了68%的差异.
- 呼吸障碍的决定因素包括女性性别,更高的BMI,更长的疾病持续时间,刚性,先前的肺部疾病和焦虑. 迪斯图西亚与肺部疾病,COVID-19症状,吞和语音投诉有关.
结论:
- 呼吸障碍和呼吸障碍在帕金森病 (PD) 中很常见,需要增加临床关注.
- 积极查与呼吸障碍和呼吸障碍相关的因素,可以帮助更早地识别和治疗PD呼吸功能障碍.
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