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Updated: May 21, 2025

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
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SWI/SNF复合体控制MYC亚型非典型的形形瘤中的本体学特定的转录因子功能

Cody L Nesvick1, Liang Zhang1, Yuqian Yan1

  • 1Department of Neurological Surgery, Mayo Clinic, Rochester, MN, USA.

Neuro-oncology
|March 23, 2025
PubMed
概括

在非典型的甲状腺瘤中,SMARCB1的丧失会破坏SWI/SNF复合体的功能,导致异常的转录因子活性. 针对这种残留活动为这些致命的大脑瘤提供了一个新的治疗策略.

关键词:
这就是为什么我们会这样做.在这种情况下,染色染色素表观遗传学是指表观遗传学.这种瘤是rhabdoid瘤.转录因子是一种转录因子.

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