相关实验视频
Updated: May 21, 2025

07:27
Accurate Follicle Enumeration in Adult Mouse Ovaries
Published on: October 16, 2020
8.2K
建立基线:了解多种哺乳动物物种的毛囊激活形态学
Hana Kubo1,2,3, Christopher J McCauley1,2,3,4, Mary B Zelinski5,6
1Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Biology of reproduction
|March 23, 2025
概括
在小鼠和其他物种中发现了一种新的"拉链"毛囊阶段,通过颗粒状细胞形状来识别. 这一发现有助于理解早期的卵泡发育和生育能力的保护.
科学领域:
- 生殖生物学 生殖生物学
- 发育生物学是发展生物学.
- 比较解剖学的比较解剖学.
背景情况:
- 毛囊生成涉及复杂的卵细胞生长和成熟阶段,由体细胞支持.
- 在小鼠的原始和过渡阶段之间,已经确定了一种新的卵泡阶段,称为"zip".
- "拉链"阶段的特征是""颗粒状细胞形态,表明第一个细胞分裂和从状转变为立方形状.
研究的目的:
- 在多种物种中识别和描述"拉链"和过渡性卵泡阶段.
- 为了比较物种之间的早期毛囊发育过程中的生长动态和形态变化.
- 建立识别这些早期卵泡阶段的参数,用于未来的生育保护研究.
主要方法:
- 猪,牛, rhesus和人类卵巢的卵巢部分的组织学检查.
- 基于颗粒细胞形态学的"拉链"和过渡性毛囊阶段的识别和特征.
- 测量卵细胞直径和面积,颗粒细胞数量和高度,以及卵泡阶段分布.
主要成果:
- 在所有研究物种 (猪,牛, rhesus,人类) 中确定了"拉链"和过渡性卵泡阶段.
- 观察到保存的生长动态,在卵细胞生长和花质细胞增殖时间方面存在特定物种的变化.
- 卵巢皮层中"拉链"和过渡性毛囊的比例差异表明物种依赖的激活机制.
结论:
- "拉链"毛囊阶段和相关的生长动态在几个哺乳动物物种中保持着.
- 早期毛囊发育的特定物种差异凸显了对激活和生长机制进一步研究的需要.
- 定义了"zip"和过渡阶段的参数,作为研究影响原始卵泡激活和生育恢复的因素的宝贵工具.
相关概念视频
Folliculogenesis
452
Folliculogenesis is the development of ovarian follicles, the specialized structures within the ovarian cortex where oogenesis, or egg development, occurs. This process is essential for female reproductive health and begins during fetal development when primordial follicles are formed. Each primordial follicle comprises a primary oocyte in the center, surrounded by a single layer of squamous pre-granulosa cells. These follicles remain dormant in late prophase I of meiosis until triggered by...
452
Multipotency and Niche of Bulge Stem Cell
3.3K
A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
3.3K

