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发育规划:早期暴露于生物固体中的真实生活化学物质的机制在后代的卵巢动力学†

Yiran Zhou¹, Katherine M Halloran¹, Michelle Bellingham²

¹Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA.

Biology of reproduction

|March 23, 2025

概括

通过生物固体处理的牧场 (BTP) 对环境化学物质 (EC) 的孕期暴露会改变后代的卵巢毛囊健康. 虽然青少年BTP后代显示出亡和自的增加,但成年BTP后代表现出正常的卵泡激活,表明持久的影响.

科学领域:

生殖生物学生殖生物学
毒理学毒理学毒理学
发展生物学发展生物学

背景情况:

女人的生殖能力取决于卵巢储备和卵泡发育.
卵巢储备的枯竭与卵泡激活和缩有关,这些过程受到环境化学物质 (EC) 的影响.
同时暴露于多个ECs需要现实的暴露模型来研究形模式.

研究的目的:

调查孕期暴露于环境化学物质 (ECs) 对卵巢卵泡缩途径从青少年到成年人的影响.
为了确定母体暴露于生物固体处理的牧场 (BTP) 是否会影响后代卵巢的亡,自,铁亡和繁殖.
了解EC暴露对女性生殖健康的长期影响.

主要方法:

从BTP或对照牧场上放牧的母羊的青少年和成年后代收集了卵巢.
用形态特征来评估毛囊缩症.
分析了细胞亡 (CASP3),自 (LC3),铁亡 (GPX4) 和扩散 (Ki67) 的分子标志物.

主要成果:

与对照组相比,青少年BTP后代显示出较高的亡和自,以及较低的增殖率.
成年BTP后代表现出较低的自和较高的铁亡,与对照组相比,细胞亡或扩散没有显著差异.
成年人比青少年有较低的亡和更高的铁亡,不论治疗组.

结论:

通过BTP的孕期EC暴露会影响青少年和成年后代的毛囊缩的独特分子途径.
成年BTP后代的低自和持续增殖可能有助于卵巢储备的正常化.
这些发现凸显了妊娠期EC暴露对后代卵泡健康和生殖潜力的持久影响.

关键词:

生物固体是一种生物固体.环境化学混合物环境化学混合物毛囊性缩症毛囊性缩症卵巢的卵泡是卵巢的卵泡.

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