大麻滥用/依赖与勃起功能障碍和丸激素缺乏风险的关联使用大型索赔数据库分析
Ryan Davis1, Jacob Hershenhouse1, Marissa Maas2
1Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089, United States.
The journal of sexual medicine
|March 23, 2025
概括
滥用和依赖大麻与更高的勃起功能障碍 (ED) 和缺乏症 (TD) 风险有关. 这些发现表明,影响男性性健康结果的重要关联.
科学领域:
- 男人性健康 男人性健康
- 药物滥用研究 药物滥用研究
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 大麻使用很普遍,但其对男性性健康的影响,特别是勃起功能障碍 (ED) 和缺乏症 (TD),由于相互矛盾的研究和小样本大小,仍然不清楚.
- 关于大麻和男性性健康的现有研究呈现出混合的结果,并且通常涉及有限的参与者数量.
研究的目的:
- 调查大麻滥用/依赖与ED风险之间的关联,化酶-5抑制剂 (PDE5-i) 处方,TD和替代疗法 (TRT).
- 使用大规模,基于人口的分析来评估这些关系.
主要方法:
- 使用TrinetX索赔数据库进行了人口层面的分析,采样了18岁及以上的男性.
- 根据大麻滥用/依赖的诊断,患者被划分为队列,用于控制49个因素的倾向性得分匹配.
- 对ED,TD,PDE5-i处方和TRT的风险进行了诊断后3个月-1年和3-5年的比较,Kaplan-Meier分析评估了ED和TD发展的时间.
主要成果:
- 大麻滥用/依赖与ED (RR=3.99),TD (RR=2.19) 和PDE5-i处方 (RR=3.80) 在3个月-1年内增加的风险显著相关.
- 在3-5年内,大麻滥用/依赖仍然与ED相关 (RR=1.20).
- 卡普兰-梅尔分析显示,在大麻滥用/依赖患者中,ED (HR=1.65) 和TD (HR=1.34) 的发展时间显著缩短.
结论:
- 这项研究支持大麻滥用/依赖与ED和TD风险增加之间存在显著的关联.
- 医疗保健提供者在治疗被诊断患有ED或TD的患者时应考虑这一关联.
- 大麻滥用/依赖与ED,TD和PDE5-i处方的可能性更高有关.
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