化学疗法诱导儿童中毒性的模式与温格萨尔科马:一个案例系列
Rabiha Manzoor1, Shaista Naz1, Sobia Ali1
1Department of Pediatric Hematology & Oncology, CMH, Rawalpindi, Pakistan.
Journal of Ayub Medical College, Abbottabad : JAMC
|March 23, 2025
概括
患有尤宁肉瘤 (骨癌) 的年幼儿童经历更多的化疗副作用,特别是5岁以下的儿童. 中性贫血性败血症是死亡的一个关键因素,需要警的感染管理.
科学领域:
- 儿科瘤学 儿科瘤学
- 癌症研究 癌症研究
- 临床毒理学 临床毒理学
背景情况:
- 尤文肉瘤是一种罕见的,侵袭性的儿科癌症,影响骨和软组织.
- 发病率各不相同,大约在英格兰每百万人口中为1.2-2.9%,在美国每百万人口中为1%.
- 了解化疗毒性对于管理儿童这种具有挑战性的疾病至关重要.
研究的目的:
- 调查儿科尤宁肉瘤患者化疗诱导的毒性模式.
- 确定患者年龄和性别对这些毒性的发生和严重性的影响.
- 确定与这一群体死亡率相关的关键因素.
主要方法:
- 一个描述性的案例系列,涉及59名被诊断患有尤文肉瘤的儿童.
- 所有患者都接受了VIDE (温克里斯,伊福斯法米德,多克索鲁比,埃托) 化疗.
- 使用统计分析,包括奇平方测试,来评估年龄和性别对毒性和死亡率的影响.
主要成果:
- 年龄较小,特别是5岁以下,与化学疗法毒性更高的发病率显著相关 (p<0.05).
- 最常见的不良事件包括中性质衰竭 (89.9%),恶心/吐 (62.7%),血小板衰竭 (61.0%),腹 (61.0%).
- 中性贫血性败血症和腹被确定为死亡率的显著预测因素.
结论:
- 儿科尤文肉瘤化疗中常见的毒性包括中性质减退,恶心/吐,粘膜炎,血小板减少和腹.
- 年龄较小的儿童 (<5岁) 面临化学疗法诱导毒性的风险增加,而性别并没有显著影响毒性模式.
- 对感染的积极管理,特别是中性贫血性败血症,对于改善儿科尤宁肉瘤患者的生存率至关重要.
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