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在中国男性不孕症患者中优化Y染色体微删除查:一项关于发病率的大规模多中心研究

Wei-Kang Chen¹, Zu-Bo Liu², Tong-Tong Lin¹

¹Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, People's Republic of China.

Human reproduction (Oxford, England)

|March 23, 2025

概括

这项研究确定了在男性不孕症中选Y染色体微切除 (YCMs) 的最佳精子度值. 关键门包括ROC最佳查的0.45百万/毫升,高灵敏度的800万/毫升和成本效益的100万/毫升.

科学领域:

生殖医学生殖医学
临床遗传学临床遗传学
安德罗学与人类学

背景情况:

Y染色体微切除 (YCMs) 是男性不孕症的一个重要遗传原因.
目前的YCM查门缺乏强有力的证据支持,导致临床争议.

研究的目的:

确定最佳的精子度值,用于查男性不孕症患者的Y染色体微删除 (YCMs).
用ROC分析评估YCMs的精子度预测性能.

主要方法:

一项追溯的多中心队列研究,涉及6806名接受生育评估和AZF基因测试的男性患者.
接收器操作特征 (ROC) 分析,以评估精子度在预测AZF删除中的有效性.
对各种精子度值的灵敏度,特异性,PPV和NPV的计算.

主要成果:

精子度有效地预测了AZF删除 (AUC:0.75).
确定了三个临床相关的值:ROC-最佳 (0.45百万/毫升),高灵敏度 (8百万/毫升) 和成本效益 (1百万/毫升).
黄毛病的发病率与精子度有显著差异,从13.35% (0-1万/毫升) 到3.56% (1-5万/毫升).

结论:

该研究提供了在男性不孕症中YCM查的基于证据的值.
这些发现有助于优化对不育男性的诊断策略和生殖咨询.
建议在不同人群中进行进一步的验证,并考虑不同医疗保健系统的成本效益.

关键词:

在AZF,AZF就是AZF.在Y染色体中发生微删除.亚精子缺血症 (Azoospermia) 是一种经济效益性经济效益性类动物精子缺血症

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