在患有支气管切除症和Mycobacterium avium复杂肺部感染的患者中,支气管镜检测吸气
Leah Lande1, Spencer Whealon2, Eden Singer2
1Division of Pulmonary and Critical Care Medicine, Lankenau Medical Center, Wynnewood, USA.; Lankenau Institute for Medical Research, Wynnewood, USA..
胃食道逆流和吸收与支气管切除和Mycobacterium avium复合体 (MAC) 肺部感染有关. 支气管镜检查期间的一种新的蓝色染料测试可以帮助诊断肺部疾病中的吸气.
科学领域:
- 肺部病理学 肺部病理学
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
背景情况:
- 支气管切除症和Mycobacterium avium复合体 (MAC) 肺部感染是严重的呼吸系统疾病.
- 胃食道逆流 (GER),喉回流 (LPR) 和吸收在它们的发病过程中的作用需要进一步调查.
研究的目的:
- 确定GER,LPR和吸入是否有助于支气管炎和MAC肺部感染的发展.
- 评估一种新的诊断方法,用于识别肺部疾病患者的吸气.
主要方法:
- 一项前性病例控制研究,涉及31名支气管切除症患者和9名接受支气管镜检查的对照患者.
- 患者在支气管镜检查前一晚摄入了蓝色染料;支气管粘膜被检查是否有染料染色.
- 气管支气管洗 (BAL) 和胃吸液样本被收集用于菌根菌培养,素和胆酸分析.
主要成果:
- 与对照组 (11.3%) 相比,在患有MAC感染 (93.8%) 和支气管炎 (91.7%) 的患者中观察到支气管粘膜有显著的蓝色染色.
- 在MAC患者中发现了更高的中位数BAL素 (5.4 ng/mL vs. 3.4 ng/mL) 和胆酸度 (>0.493 uM在78.6%的MAC患者中).
- 在CT扫描异常和蓝色染料染色之间发现了相关性,42.8%的MAC患者在BAL和胃吸收中显示MAC增长.
结论:
- 胃内含物的反流和吸收与支气管病症密切相关,可能在MAC肺部疾病中发挥作用.
- 蓝色染料方法是评估炎症和传染性肺部疾病中吸气的有希望的工具.
更多相关视频
04:10Author Spotlight: Expanding Interventional Pulmonology Research with Robotic-Assisted Bronchoscopy
Published on: July 19, 2024
07:21Processing of Bronchoalveolar Lavage Fluid and Matched Blood for Alveolar Macrophage and CD4+ T-cell Immunophenotyping and HIV Reservoir Assessment
Published on: June 23, 2019
相关概念视频
Pulmonary Tuberculosis IV
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis II
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
Medical History
Pulmonary Tuberculosis I
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Sputum Studies I: Gram Stain, cytology, and Acid-fast smear and culture
Gram Stain
The Gram Stain is an integral part of sputum studies. It involves the staining of sputum, which permits...
Endoscopic Studies I: Bronchoscopy and Thoracoscopy
Bronchoscopy
Description
Bronchoscopy is a procedure that involves direct visualization of the larynx, trachea, and bronchi for diagnostic and therapeutic purposes. A flexible fiber optic or rigid bronchoscope is used to carry out the procedure. The fiber-optic bronchoscope is more frequently used due...
