静脉血栓栓塞及其慢性后果的代谢学概况 - 一个系统的审查
Zahra Amirsardari1, Asal Khalili2, Mohammadhasan Sharafi3
1Cardiogenetic Research Center, Rajaie Cardiovascular Institute, Tehran, Iran; School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Congenital Heart Disease Research Center, Rajaie Cardiovascular Institute, Tehran, Iran.
Thrombosis research
|March 23, 2025
概括
代谢学研究揭示了静脉血栓栓塞 (VTE) 和其并发症中的代谢障碍. 受影响的关键途径包括氨基酸和碳水化合物代谢,为疾病进展提供了洞察力.
科学领域:
- 生物化学 生物化学
- 基因组学就是基因组学.
- 系统生物学 系统生物学
背景情况:
- 高通量代谢学推进了静脉血栓形成的生物标志物发现.
- 了解静脉血栓塞栓症 (VTE) 和其后果 (CTEPH,PTS) 的发病性至关重要.
- 本综述综合了VTE,CTEPH和PTS中的代谢学研究.
研究的目的:
- 系统地审查和总结静脉血栓塞栓症 (VTE) 的代谢学研究.
- 为了确定VTE及其慢性后果中的代谢障碍和受影响的途径.
- 涵盖临床前和临床研究.
主要方法:
- 在PubMed,Embase,Scopus和Web of Science中进行系统的文献搜索.
- 使用SYRCLE进行动物研究和QUADOMICS进行人体研究进行质量评估.
- 在PROSPERO注册的研究协议 (CRD42024529490).
主要成果:
- 在细胞呼吸,碳水化合物,氨基酸,脂质和核酸代谢中发现了代谢障碍.
- 观察到血清氨基酸和三碳酸 (TCA) 循环代谢物的频繁变化.
- 路径丰富分析突出显示了氨酸,氨酸,单氨酸,氨酸,阿斯巴甜酸,d-glutamine,D-glutamate和氨酸的代谢.
结论:
- 提供了VTE和其慢性后果中的代谢组的全面概述.
- 确定关键的代谢途径与VTE疾病进展有关.
- 强调了新陈代谢失调在静脉血栓栓塞状况中的作用.
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