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暴露于二二和帕拉混合物与成年人肺功能之间的关联来自NHANES,2007-2012年

Xinwei Li¹, Meiyun Nie¹, Keke Yang¹

¹Department of Geriatrics, Shanghai Fourth People's Hospital affiliated to Tongji University, Shanghai, China.

Heart & lung : the journal of critical care

|March 23, 2025

概括

暴露于二二和类与成年人肺功能减弱有关. 这项研究强调了这些常见化学品单独或组合对呼吸系统健康的负面影响.

科学领域:

环境健康环境健康
毒理学毒理学毒理学
肺部医学肺部医学

背景情况:

关于二二和对肺功能的影响的研究有限.
大多数先前的研究都集中在单个化学物质暴露上,而不是混合物.

研究的目的:

分析单次和混合暴露于二二和类对成年人肺功能的影响.
研究这些化学物质在尿液中的含量与呼吸系统健康指标之间的关联.

主要方法:

利用了2007-2012年国家健康和营养检查调查 (NHANES) 的数据.
采用了通用线性回归 (GLM),加权量子素和回归 (WQS) 和贝叶斯内核机器回归 (BKMR) 模型.
在肺功能测量 (FVC,FEV1) 旁边,评估了二二和帕拉宾的尿液水平.

主要成果:

分析包括2599名成年人,他们对2,5-二二 (2,5-DCP),2,4-二二 (2,4-DCP),甲基和类的检测率很高.
GLMs表明2,5-DCP与1秒内强迫生命能力 (FVC) 和强迫呼吸量 (FEV1) 的下降有显著关联.
WQS和BKMR模型证实了化学混合物与肺功能 (FVC和FEV1) 之间的负相关性.

结论:

暴露在单独或组合的二二和类中,与人类的肺功能下降有关.
研究结果表明,对这些化学物质的环境暴露可能对呼吸系统健康构成风险.

关键词:

贝叶斯核机器回归贝叶斯核机器回归这是一种二二醇.一般化的线性回归.肺功能肺功能肺功能帕拉本类药物可以权重定量积回归权重的定量积回归.

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