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预测需要额外的术后治疗的预测因子 埃索诺菲尔慢性鼻炎
Takahiro Saito1, Katsuya Fushimi1, Tomoki Hirose1
1Department of Otorhinolaryngology, Head and Neck Surgery, Hyogo Medical University, Nishinomiya, Japan.
概括
早期干预是治疗异性慢性鼻炎 (ECRS) 的类固醇有效性的关键. 杜皮卢马布或修复手术在耐固醇病例中提供了可比的结果,这凸显了 ECRS 患者及时治疗的重要性.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 乳性慢性鼻炎 (ECRS) 带来了治疗挑战,特别是当类固醇等初始疗法无效时.
- 确定影响类固醇反应的因素和评估替代方案,如dupilumab或修订功能内镜外科手术 (FESS) 对于患者管理至关重要.
研究的目的:
- 确定影响ECRS患者类固醇治疗有效性的因素.
- 为了评估在耐固醇患者中使用dupilumab或修订FESS的治疗结果.
主要方法:
- 在2007年至2021年期间,对118名接受初始FESS的成年ECRS患者进行了回顾性分析.
- 患者特征,症状问卷和客观检查结果的比较,在类固醇响应者和非响应者之间进行比较 (需要dupilumab或修订FESS).
主要成果:
- 与响应者相比,在非响应者中观察到从症状发作到初始FESS的持续时间显著更长 (p < 0.001).
- 两组治疗后的嗅觉和鼻腔症状均显著改善 (p < 0.05).
- 在治疗后的两组之间没有发现结果的显著差异.
结论:
- 早期治疗干预至关重要,因为初始FESS的时间会影响ECRS的类固醇治疗疗效.
- 杜皮卢马布或修复手术在耐固醇ECRS病例中,甚至在术后也可以提供与类固醇类似的结果.
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