到2024年,特尔比纳耐药Trichophyton indotineae的世界危机:我们有足够的知识吗?
Ali Abdul Hussein S Al-Janabi1
1Department of Microbiology, College of Medicine, University of Karbala, Iraq.
Critical reviews in microbiology
|March 23, 2025
概括
新发病的Trichophyton indotineae会导致广泛的皮肤植物病. 本综述探讨了与烯氧化酶 (SQLE) 基因突变相关的耐特binafine 菌株的出现和全球传播.
科学领域:
- 菌类学 菌类学是指菌类学.
- 皮肤病学 皮肤病学
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 皮肤植物病是一种常见的真菌感染,影响所有年龄段.
- 一种新的毒性皮肤植物物种Trichophyton indotineae在全球迅速蔓延.
- 抗真菌耐药性,特别是对醇的耐药性,在治疗T. indotineae感染时越来越令人担忧.
研究的目的:
- 审查特比纳耐药Trichophyton indotineae菌株的出现情况.
- 调查T. indotineae.中的特尔比纳耐药性的遗传基础.
- 绘制这些耐药菌株当前全球分布的地图.
主要方法:
- 对Trichophyton indotineae.研究的文献评论.
- 分析与特比纳耐药性相关的遗传突变,重点关注SQLE基因.
- 编制关于耐药菌株地理传播的流行病学数据.
主要成果:
- 斯夸伦环氧化酶 (SQLE) 基因的点突变被确定为特尔比纳耐药性的首要原因.
- 这些突变导致SQLE蛋白中的氨基酸替代,降低了药物的疗效.
- 在世界各地的不同地区记录了对特尔比纳胺耐药的T. indotineae菌株.
结论:
- 由于特比纳的广泛使用,人们选择了耐药的T. indotineae菌株.
- 了解耐药性的遗传机制和地理传播对于有效的治疗策略至关重要.
- 持续监测和研究是必要的,以应对日益增长的抗真菌耐药性在皮肤植物病的威胁.
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