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Updated: Jul 27, 2026

Improved Generation of Induced Cardiomyocytes Using a Polycistronic Construct Expressing Optimal Ratio of Gata4, Mef2c and Tbx5
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Improved Generation of Induced Cardiomyocytes Using a Polycistronic Construct Expressing Optimal Ratio of Gata4, Mef2c and Tbx5

Published on: November 13, 2015

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一个新的构成性平滑肌肉细胞特异的Myh11驱动的Cre鼠标模型的生成

Kunzhe Dong1, Zhixia Bai2, Xiangqin He3

  • 1Immunology Center of Georgia, Augusta University, Augusta, GA 30912, USA; Department of Pharmacology & Toxicology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.

Journal of molecular and cellular cardiology
|March 23, 2025
PubMed
概括

一个新的Myh11驱动的Cre小鼠模型精确地针对基因研究的光滑肌肉细胞 (SMCs). 这种强大的工具可以在胚胎发育期间在SMC中准确地追踪血统和基因操纵,克服以前模型的局限性.

关键词:
创意的创意,就是创造的.胚胎发育的时间这是一次敲门入场.我的11 个小时肌素重链蛋白质的存在平滑肌肉的肌肉是平滑的你知道吗?你知道吗?转录因子是一种转录因子.

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...