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抑郁症的脆弱性和灰质整合体内接收网络在缓解抑郁症的门诊患者

Liliana C Wu¹, Zindel V Segal², Norman A S Farb³

¹Department of Psychology, University of Toronto Mississauga, 3359 Mississauga Road, Mississauga, Ontario L5L 1C6, Canada.

Journal of affective disorders

|March 23, 2025

概括

重度抑郁症 (MDD) 复发的脆弱性与大脑感官区域灰质厚度的增加有关. 基于正念的认知疗法 (MBCT) 可能促进灰质的生长,可能有助于恢复.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
心理健康研究心理健康研究

背景情况:

内感,即对身体内部状态的意识,对心理健康至关重要.
功能神经成像表明,压力对重度抑郁症 (MDD) 复发中的感觉运动区域产生影响.
在MDD中,整体受体网络中的结构性大脑变化尚未得到充分理解.

研究的目的:

调查灰质体积与MDD缓解患者复发脆弱性之间的关系.
探索心理治疗干预如何影响与MDD复发相关的结构性大脑变化.

主要方法:

对接受认知行为疗法或基于正念的认知疗法 (MBCT) 的85名缓解的MDD患者的二次分析.
在八周的治疗期间获得了两项数据,随后进行了为期两年的随访.
混合效应模型分析了皮质厚度,时间和干预类型,与复发,症状和脱中心化有关.

主要成果:

较大的皮层厚度在左侧胰岛和左前尾与MDD复发相关.
剩余症状与左侧岛屿和右侧前中心区域的厚度增加有关.
随着时间的推移,MBCT参与者在右上旋中表现出皮质厚度的增加.

结论:

患MDD的脆弱性与感官和前额叶区域皮质厚度的增加有关,这可能表明不适应性技能获得.
基于正念的认知疗法 (MBCT) 可能会增强右上部的灰质体积.

关键词:

皮层厚度皮层厚度抑郁症抑郁症抑郁症灰色物质是一种灰色物质.间接接收录 (interoception) 是一种对接接收录.互感器功能障碍互感器功能障碍复发的脆弱性复发的脆弱性

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