相关实验视频
Updated: Jun 29, 2026

14:33
The Subventricular Zone En-face: Wholemount Staining and Ependymal Flow
Published on: May 6, 2010
41.9K
嗅球内部神经元 - 由胚胎神经发生所定义的发育时间表和向
Natalie J Spence1, Eduardo Martin-Lopez1, Kimberly Han1
1Department of Neurosurgery, Yale University School of Medicine, 310 Cedar St., New Haven, CT 06510, United States of America; Department of Neuroscience, Yale University School of Medicine, 100 College Street, New Haven, CT 06520, United States of America.
Molecular and cellular neurosciences
|March 23, 2025
概括
胚胎嗅球 (OB) 内神经元 (INs) 从胚胎第10天开始产生,并填充所有OB层. 这些IN在产后慢慢成熟,影响嗅觉系统的发育.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 嗅觉系统研究 嗅觉系统研究
背景情况:
- 嗅觉灯泡 (OB) 内神经元 (IN) 对于嗅觉处理至关重要.
- 虽然产后的IN产生得到了很好的研究,但对胚胎IN发育的理解仍然较少.
- 胚胎INs有助于OB电路的形成和嗅觉功能.
研究的目的:
- 研究胚胎OB INs的生成,迁移,分化和分布.
- 描述从原生细胞到成熟细胞的胚胎INs的发育时间表.
- 了解胚胎INs对OB电路发展的贡献.
主要方法:
- 孕产妇注射蒂米丁类同类药物以根据出生日期标记IN.
- 免疫组织化学分析IN目的地和成年OB的表型.
- 在子宫内进行电穿孔,以追踪神经细胞迁移和分化.
- 对特定的分子标记物 (calbindin,parvalbumin等) 的分析. 对于IN的到期期.
主要成果:
- 胚胎INs在整个胚胎发育过程中从E10生成,并在成年OB中保留.
- 胚胎IN分布在所有OB层中,具有暂时的横向偏好 (E11-E13) 和偏好的表面GCL局部化.
- 神经母细胞通过E13迁移到OB,通过E15分化,通过E16可见胚胎面向迁移流 (RMS).
- 缺乏成熟标志物的共同表达表明胚胎INs的出生后成熟缓慢.
结论:
- 胚胎IN在建立OB电路方面发挥着重要作用.
- 了解胚胎IN发育对于理解嗅觉系统功能至关重要.
- 在特定的胚胎时间窗口内研究IN对于详细的电路分析至关重要.
相关概念视频
Olfaction
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
The olfactory receptors are embedded in the cilia of the...
Neurulation
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the anterior...
Olfactory Receptors: Location and Structure
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...

