从驱逐剂到风险:DEET对儿童激素和骨健康的不良影响
Xinyu Zhu1, Wanlu Liu1, Baihao Lin1
1School of Public Health, Guangzhou Medical University, Xinzao, Panyu District, Guangzhou 511436, China.
Journal of advanced research
|March 23, 2025
概括
暴露于N,N-二甲基-3-甲基胺 (DEET) 通过破坏性激素,对儿童和青少年的骨健康产生负面影响. 这项研究强调了与DEET使用相关的潜在风险,特别是在年轻人和没有超重的个体中.
科学领域:
- 内分泌学 在内分泌学.
- 环境健康 环境健康
- 儿科 儿科 儿科
背景情况:
- 早期的骨质积累对于预测未来的脆弱性骨折风险至关重要,并且与性激素有关.
- N,N-二甲基-3-甲基胺 (DEET) 是一种广泛使用的杀虫剂,特别是在儿童中,但它对性激素和骨健康的影响尚不清楚.
研究的目的:
- 调查DEET暴露对儿童和青少年骨质的不良影响.
- 确定性激素在DEET暴露和骨质之间关系中的调解作用.
主要方法:
- 从2013-2016年NHANES中对864名儿童和青少年进行了横截面分析.
- 用尿中的3-乙基-碳基酸 (DCBA) 作为DEET暴露的生物标志物.
- 检查了DCBA,性激素 (,雌激素,SHBG) 和骨质 (BMD,BMC) 之间的关联,包括调解分析.
主要成果:
- 增加的DCBA水平与降低的,雌激素和自由雄激素指数以及增加的SHBG相关,特别是在12岁以下的儿童和非超重个体中.
- 在没有超重的参与者中观察到DCBA和骨质 (BMD/BMC) 之间的负剂量反应关系,在12岁以下的儿童中观察到BMC.
- 性激素 (,雌激素,SHBG) 在DEET-骨质关联中显著调解了15.41%至79.84%,也检测到了串行调解效应.
结论:
- 暴露于DEET会通过破坏性激素平衡,对儿童和青少年的骨健康产生不利影响.
- 研究结果表明,需要提高公众对DEET对骨发育的潜在风险的认识.
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