结构网络枢纽作为放射治疗后质瘤患者潜在的危险器官
Laurien De Roeck1, Jeroen Blommaert2, Patrick Dupont3
1Department of Radiation-Oncology, University Hospitals Leuven, Leuven, Belgium; Department of Oncology, KU Leuven, Leuven, Belgium; Department of Radiation-Oncology, AZ Turnhout, Turnhout, Belgium.
概括
对大脑网络枢纽的辐射疗法 (RT) 剂量与质瘤患者的认知衰退有关. 将这些关键大脑区域隔开可能会在治疗后保持认知功能.
科学领域:
- 神经瘤学神经瘤学
- 辐射疗法 辐射疗法
- 认知神经科学 认知神经科学
背景情况:
- 在放射治疗 (RT) 后,对质瘤患者来说,认知后果是一个重要的关注点.
- 识别在RT期间需要节省的关键大脑区域对于保持认知功能至关重要.
- 结构性大脑网络枢纽被探索为潜在的风险器官.
研究的目的:
- 调查放射治疗剂量与结构性大脑网络枢纽之间的关联.
- 探索质瘤患者网络变化和认知结果之间的关系.
主要方法:
- 对39名成年质瘤患者和50名健康对照者的横截面研究.
- 在RT后≥1年评估的认知领域:语言,记忆,注意力,运动和执行功能.
- 多层扩散加权成像用于构建加权结构图和定义枢纽;线性回归和斯皮尔曼相关性分析了RT剂量-节点强度-认知关系.
主要成果:
- 增加RT剂量与9个大脑区域的节点强度下降相关,主要影响枢纽.
- 较差的执行性能和注意力与特定左侧区域 (前中心,后中心,后带皮层) 的更高RT剂量有关.
- 与较高的RT剂量与左侧胰岛,上额头和前中心结相关的语言结果减少.
结论:
- 较高的RT剂量对特定的大脑区域,特别是左侧枢纽,与网络中心性降低和认知能力受损相关.
- 这些发现表明,节省网络或枢纽RT剂量规划的潜在好处.
- 建议进行进一步的纵向研究,以验证这些发现的临床应用.
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