神经退行性疾病的基于液体的生物标志物
Yongliang Cao1, Yifei Xu2, Meiqun Cao3
1Lingang Laboratory, Shanghai 200120, China.
Ageing research reviews
|March 23, 2025
概括
液体生物标志物提供早期检测神经退行性疾病,如阿尔茨海默氏症和帕金森氏症. 血液检测的进步显示出对可访问的诊断和个性化医疗的承诺,尽管目前的研究挑战仍在继续.
科学领域:
- 神经学 神经学
- 生物标志物研究 生物标志物研究
- 个性化医疗是个性化的医疗.
背景情况:
- 神经退行性疾病 (阿尔茨海默氏症,多发性硬化症,帕金森症,ALS) 正在随着人口老龄化而上升.
- 来自CSF,血液和其他来源的液体生物标志物可以早期检测病理变化.
- 这些生物标志物反映了关键过程,如粉样β沉积和高酸化.
研究的目的:
- 审查神经退行性疾病的液体生物标志物的现状.
- 突出基于血液的生物标志物的进展及其诊断潜力.
- 讨论挑战,伦理考虑和该领域的未来方向.
主要方法:
- 对神经退行性疾病的液体生物标志物的当前文献的综述.
- 分析各种液体生物标志物的诊断准确性,包括基于血液的测试.
- 探索诸如变性,标准化和敏感性等挑战.
主要成果:
- 基于血液的生物标志物 (血Aβ,p-tau,TDP-43) 的诊断准确度与CSF相比较.
- 结合多个生物标志物和临床数据可以提高诊断可靠性.
- 细胞外囊泡 (EV) 和人工智能集成是新兴领域.
结论:
- 液体生物标志物对于神经退行性疾病的早期诊断和监测至关重要.
- 克服标准化和敏感性方面的挑战是临床实施的关键.
- 未来的研究重点是多生物标志物面板和人工智能,将推动个性化医疗.
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