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Updated: Aug 2, 2026

Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library
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类仿制剂的设计和表征:桥梁实验和基于计算机的方法

Alice Romagnoli1, Jesmina Rexha1, Nunzio Perta1

  • 1Department of Life and Environmental Sciences, Polytechnic University of Marche, Ancona, Italy; New York-Marche Structural Biology Centre (NY-MaSBiC), Polytechnic University of Marche, Ancona, Italy; Neuronal Death and Neuroprotection Unit, Department of Neuroscience, Mario Negri Institute for Pharmacological Research-IRCCS, Milan, Italy.

Progress in molecular biology and translational science
|March 23, 2025
PubMed
概括

类模拟剂提供了改进的药物特性,通过向蛋白质-蛋白质相互作用来增强治疗疾病的输送和特异性. 这些先进的分子代表了精密药物发现和开发的前沿.

关键词:
计算方法的计算方法.药物设计 药物设计PPI 抑制剂 PPI 抑制剂的修改 的修改基于的治疗方法类模拟剂 类模拟剂 类模拟剂

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Protein-protein Interfaces02:04

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...