口服提供蛋白质和治疗药物
Vivek P Chavda1, Pankti C Balar2
1Department of Pharmaceutics and Pharmaceutical Technology, L. M. College of Pharmacy, Ahmedabad, Gujarat, India.
Progress in molecular biology and translational science
|March 23, 2025
概括
口服的蛋白质和类药物面临来自胃肠道的挑战. 像纳米粒子系统和化学修饰等创新策略正在改善稳定性和吸收性,以获得更好的治疗结果.
科学领域:
- 生物制药物供应提供.
- 药物配方科学 药物配方科学
- 纳米技术在医学中的应用
背景情况:
- 口服蛋白质和提供了一个非侵入性的治疗方法.
- 胃肠道的恶劣条件 (酸性pH,酶) 限制了口服生物制药的疗效.
- 重要的障碍包括酶降解和肠道透性差.
研究的目的:
- 审查口服蛋白质和类药物输送方面的进展.
- 突出克服胃肠道障碍的战略.
- 讨论该领域的挑战和未来方向.
主要方法:
- 基于纳米粒子的输送系统 (脂质体,聚合纳米粒子,固体脂质纳米粒子) 的探索.
- 使用色素和酸盐等聚合物的粘粘剂配方的研究.
- 化学修饰的分析,如PEGylation,糖化和脂化.
- 考虑智能纳米载体和计算建模.
主要成果:
- 纳米粒子保护药物免受降解,并提高生物可用性.
- 粘粘剂配方增加药物停留时间和吸收.
- 化学修改可以提高的稳定性和透性.
- 纳米技术和计算方法的进步优化了交付系统.
结论:
- 创新策略对于克服口语交付挑战至关重要.
- 纳米技术和先进配方对治疗性蛋白质和具有显著的前景.
- 需要进一步的研究才能充分实现口服蛋白质和类药物递送的潜力.
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