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Updated: May 20, 2025

In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones
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Published on: July 25, 2019

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通过调解BAP1的在位依赖性退化,VCP促进胆管癌的发展

Peiying Zhang1, Xiangning Liu1, Yue Liu1

  • 1Institute of Pharmacology & Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.

Cancer science
|March 23, 2025
PubMed
概括

研究人员确定了含有瓦洛辛的蛋白质 (VCP) 作为胆管癌 (CCA) 治疗的目标. 阻断VCP通过阻止瘤抑制剂BAP1的降解来抑制瘤生长,为CCA提供了一个新的治疗策略.

关键词:
在 BAP1 中, BAP1 是 BAP1 的前身.这是一个VCPVCP.细胞亡是细胞的亡.胆瘤是一种胆瘤.无处不在的化

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